Literature DB >> 2732725

Lithium alters the stereoselectivity of monoamine oxidase in rat brain.

D F Smith1.   

Abstract

The effects of lithium on monoamine oxidase (MAO) in rat brain were studied in the presence of each enantiomer of tranylcypromine [(+)- and (-)-TCP]. The (+)-enantiomer was 25 times more potent than its antipode as MAO inhibitor. Lithium enhanced the inhibitory effect of (-)-TCP on MAO, but it did not affect actions of the (+)-enantiomer. Moreover, lithium influenced the stereoselective index for MAO, which suggests that lithium altered conformational features of the enzyme.

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Year:  1989        PMID： 2732725     DOI： 10.1007/bf01260505

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  15 in total

1.  A simplified method of evaluating dose-effect experiments.

Authors:  J T LITCHFIELD; F WILCOXON
Journal:  J Pharmacol Exp Ther       Date:  1949-06       Impact factor: 4.030

2.  The preferred conformation of noradrenaline.

Authors:  L Pedersen; R E Hoskins; H Cable
Journal:  J Pharm Pharmacol       Date:  1971-03       Impact factor: 3.765

3.  Lithium, animal behavior and monoamines: five questions and possible ways of answering them.

Authors:  D F Smith
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1985

4.  Increased human platelet monoamine oxidase activity during lithium carbonate therapy.

Authors:  J Bockar; R Roth; G Heninger
Journal:  Life Sci       Date:  1974-12-15       Impact factor: 5.037

Review 5.  NEUTRAL SALTS: THE GENERALITY OF THEIR EFFECTS ON THE STABILITY OF MACROMOLECULAR CONFORMATIONS.

Authors:  P H VONHIPPEL; K Y WONG
Journal:  Science       Date:  1964-08-07       Impact factor: 47.728

6.  The effect of lithium on platelet monoamine oxidase activity in bipolar and schizoaffective disorders.

Authors:  H Y Meltzer; P Tueting; H Jackman
Journal:  Br J Psychiatry       Date:  1982-02       Impact factor: 9.319

7.  Increased platelet monoamine oxidase activity in affective disorders.

Authors:  M A Reveley; V Glover; M Sandler; A Coppen
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

8.  Effects of alpha methyltyrosine and parachlorophenylalanine on open field behavior in rats given tranylcypromine stereoisomers and lithium carbonate.

Authors:  D F Smith; M Shimizu
Journal:  Pharmacol Biochem Behav       Date:  1976-11       Impact factor: 3.533

9.  Dopamine metabolism in human brain: effect of monoamine oxidase inhibition in vitro by (-)deprenyl and (+) and (-) tranylcypromine.

Authors:  G P Reynolds; P Riederer; W D Rausch
Journal:  J Neural Transm Suppl       Date:  1980

10.  A comparison of the pharmacological and biochemical properties of substrate-selective monoamine oxidase inhibitors.

Authors:  A J Christmas; C J Coulson; D R Maxwell; D Riddell
Journal:  Br J Pharmacol       Date:  1972-07       Impact factor: 8.739
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  1 in total

1.  Effects of 3,N,N'-trimethyl-2-phenyl-1,4-piperazine diastereomers on monoamine uptake and monoamine oxidase in rat brain.

Authors:  D F Smith; P N Jensen; M Gelbcke; D Tytgat
Journal:  J Neural Transm Gen Sect       Date:  1992
  1 in total

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