Literature DB >> 27327157

Regulation of chromatin structure and cell fate by R-loops.

Thomas G Fazzio1,2.   

Abstract

Hybridization of RNA to its template DNA strand during transcription induces formation of R-loops-RNA:DNA hybrids with unpaired non-template DNA strands. Although unresolved R-loops can be detrimental, some R-loops contribute to regulation of chromatin structure. Consequently, R-loops help regulate gene expression and play important roles in numerous cellular processes.

Keywords:  R-loops; chromatin; embryonic stem cells; nucleosome; pluripotency

Mesh：

Substances：

Year:  2016        PMID： 27327157      PMCID： PMC4984679          DOI： 10.1080/21541264.2016.1198298

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  41 in total

1.  Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.

Authors:  Pablo Huertas; Andrés Aguilera
Journal:  Mol Cell       Date:  2003-09       Impact factor: 17.970

2.  Intrinsic coupling of lagging-strand synthesis to chromatin assembly.

Authors:  Duncan J Smith; Iestyn Whitehouse
Journal:  Nature       Date:  2012-03-14       Impact factor: 49.962

3.  Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein.

Authors:  Jamieson A L Howard; Stephane Delmas; Ivana Ivančić-Baće; Edward L Bolt
Journal:  Biochem J       Date:  2011-10-01       Impact factor: 3.857

Review 4.  Ribonuclease H: the enzymes in eukaryotes.

Authors:  Susana M Cerritelli; Robert J Crouch
Journal:  FEBS J       Date:  2008-02-18       Impact factor: 5.542

5.  Dynamics of replication-independent histone turnover in budding yeast.

Authors:  Michael F Dion; Tommy Kaplan; Minkyu Kim; Stephen Buratowski; Nir Friedman; Oliver J Rando
Journal:  Science       Date:  2007-03-09       Impact factor: 47.728

6.  Promiscuous RNA binding by Polycomb repressive complex 2.

Authors:  Chen Davidovich; Leon Zheng; Karen J Goodrich; Thomas R Cech
Journal:  Nat Struct Mol Biol       Date:  2013-09-29       Impact factor: 15.369

7.  R-loops induce repressive chromatin marks over mammalian gene terminators.

Authors:  Konstantina Skourti-Stathaki; Kinga Kamieniarz-Gdula; Nicholas J Proudfoot
Journal:  Nature       Date:  2014-10-05       Impact factor: 49.962

Review 8.  The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2.

Authors:  Chen Davidovich; Thomas R Cech
Journal:  RNA       Date:  2015-12       Impact factor: 4.942

9.  PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells.

Authors:  Syuzo Kaneko; Jinsook Son; Steven S Shen; Danny Reinberg; Roberto Bonasio
Journal:  Nat Struct Mol Biol       Date:  2013-10-20       Impact factor: 15.369

10.  R loops regulate promoter-proximal chromatin architecture and cellular differentiation.

Authors:  Poshen B Chen; Hsiuyi V Chen; Diwash Acharya; Oliver J Rando; Thomas G Fazzio
Journal:  Nat Struct Mol Biol       Date:  2015-11-09       Impact factor: 15.369
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  7 in total

1.  The Mechanical Properties of RNA-DNA Hybrid Duplex Stretched by Magnetic Tweezers.

Authors:  Chen Zhang; Hang Fu; Yajun Yang; Erchi Zhou; Zhijie Tan; Huijuan You; Xinghua Zhang
Journal:  Biophys J       Date:  2018-12-13       Impact factor: 4.033

2.  Dynamic nucleoplasmic and nucleolar localization of mammalian RNase H1 in response to RNAP I transcriptional R-loops.

Authors:  Wen Shen; Hong Sun; Cheryl L De Hoyos; Jeffrey K Bailey; Xue-Hai Liang; Stanley T Crooke
Journal:  Nucleic Acids Res       Date:  2017-10-13       Impact factor: 16.971

Review 3.  RNA Epigenetics: Fine-Tuning Chromatin Plasticity and Transcriptional Regulation, and the Implications in Human Diseases.

Authors:  Amber Willbanks; Shaun Wood; Jason X Cheng
Journal:  Genes (Basel)       Date:  2021-04-22       Impact factor: 4.096

Review 4.  Collaboration through chromatin: motors of transcription and chromatin structure.

Authors:  Nathan Gamarra; Geeta J Narlikar
Journal:  J Mol Biol       Date:  2021-02-05       Impact factor: 6.151

5.  Proximity labeling identifies a repertoire of site-specific R-loop modulators.

Authors:  Qingqing Yan; Phillip Wulfridge; John Doherty; Jose L Fernandez-Luna; Pedro J Real; Hsin-Yao Tang; Kavitha Sarma
Journal:  Nat Commun       Date:  2022-01-10       Impact factor: 17.694

6.  The Arabidopsis APOLO and human UPAT sequence-unrelated long noncoding RNAs can modulate DNA and histone methylation machineries in plants.

Authors:  Camille Fonouni-Farde; Aurélie Christ; Thomas Blein; María Florencia Legascue; Lucía Ferrero; Michaël Moison; Leandro Lucero; Juan Sebastián Ramírez-Prado; David Latrasse; Daniel Gonzalez; Moussa Benhamed; Leandro Quadrana; Martin Crespi; Federico Ariel
Journal:  Genome Biol       Date:  2022-08-29       Impact factor: 17.906

7.  Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels.

Authors:  Agnes Fütterer; Amaia Talavera-Gutiérrez; Tirso Pons; Jesús de Celis; Julio Gutiérrez; Verónica Domínguez Plaza; Carlos Martínez-A
Journal:  Cell Death Dis       Date:  2021-06-21       Impact factor: 8.469
  7 in total

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