J Paccou1,2, M H Edwards1, J M Patsch3, K A Jameson1, K A Ward4, C Moss1, E M Dennison1,5, C Cooper6,7,8. 1. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK. 2. Department of Rheumatology, Lille University Hospital, Lille 2, 59037, Lille cedex, France. 3. Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria. 4. MRC Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, UK. 5. Victoria University, Wellington, New Zealand. 6. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK. cc@mrc.soton.ac.uk. 7. NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, OX3 5UG, UK. cc@mrc.soton.ac.uk. 8. NIHR Nutrition Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Trust, Southampton General Hospital, Southampton, SO16 6YD, UK. cc@mrc.soton.ac.uk.
Abstract
In older women, the presence of lower leg arterial calcification assessed by high-resolution peripheral quantitative computed tomography is associated with relevant bone microstructure abnormalities at the distal tibia and distal radius. INTRODUCTION: Here, we report the relationships of bone geometry, volumetric bone mineral density (BMD) and bone microarchitecture with lower leg arterial calcification (LLAC) as assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT). METHODS: We utilized the Hertfordshire Cohort Study (HCS), where we were able to study associations between measures obtained from HR-pQCT of the distal radius and distal tibia in 341 participants with or without LLAC. Statistical analyses were performed separately for women and men. We used linear regression models to investigate the cross-sectional relationships between LLAC and bone parameters. RESULTS: The mean (SD) age of participants was 76.4 (2.6) and 76.1 (2.5) years in women and men, respectively. One hundred and eleven of 341 participants (32.6 %) had LLAC that were visible and quantifiable by HR-pQCT. The prevalence of LLAC was higher in men than in women (46.4 % (n = 83) vs. 17.3 % (n = 28), p < 0.001). After adjustment for confounding factors, we found that women with LLAC had substantially lower Ct.area (β = -0.33, p = 0.016), lower Tb.N (β = -0.54, p = 0.013) and higher Tb.Sp (β = 0.54, p = 0.012) at the distal tibia and lower Tb.Th (β = -0.49, p = 0.027) at the distal radius compared with participants without LLAC. Distal radial or tibial bone parameter analyses in men according to their LLAC status revealed no significant differences with the exception of Tb.N (β = 0.27, p = 0.035) at the distal tibia. CONCLUSION: In the HCS, the presence of LLAC assessed by HR-pQCT was associated with relevant bone microstructure abnormalities in women. These findings need to be replicated and further research should study possible pathophysiological links between vascular calcification and osteoporosis.
In older Species">women, the presence of lower leg arterial calcification assessed by high-resolution peripheral quantitative computed tomography is associated with relevant bone microstructure abnormalities at the distal tibia and distal radius. INTRODUCTION: Here, we report the relationships of bone geometry, volumetric bone mineral density (BMD) and bone microarchitecture with lower leg arterial calcification (LLAC) as assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT). METHODS: We utilized the Hertfordshire Cohort Study (HCS), where we were able to study associations between measures obtained from HR-pQCT of the distal radius and distal tibia in 341 participants with or without LLAC. Statistical analyses were performed separately for women and men. We used linear regression models to investigate the cross-sectional relationships between LLAC and bone parameters. RESULTS: The mean (SD) age of participants was 76.4 (2.6) and 76.1 (2.5) years in women and men, respectively. One hundred and eleven of 341 participants (32.6 %) had LLAC that were visible and quantifiable by HR-pQCT. The prevalence of LLAC was higher in men than in women (46.4 % (n = 83) vs. 17.3 % (n = 28), p < 0.001). After adjustment for confounding factors, we found that women with LLAC had substantially lower Ct.area (β = -0.33, p = 0.016), lower Tb.N (β = -0.54, p = 0.013) and higher Tb.Sp (β = 0.54, p = 0.012) at the distal tibia and lower Tb.Th (β = -0.49, p = 0.027) at the distal radius compared with participants without LLAC. Distal radial or tibial bone parameter analyses in men according to their LLAC status revealed no significant differences with the exception of Tb.N (β = 0.27, p = 0.035) at the distal tibia. CONCLUSION: In the HCS, the presence of LLAC assessed by HR-pQCT was associated with relevant bone microstructure abnormalities in women. These findings need to be replicated and further research should study possible pathophysiological links between vascular calcification and osteoporosis.
Entities:
Keywords:
Bone microstructure; High-resolution peripheral quantitative computed tomography; Lower leg arterial calcification; Volumetric bone mineral density
Authors: H Shen; L F Bielak; E A Streeten; K A Ryan; J A Rumberger; P F Sheedy; A R Shuldiner; P A Peyser; B D Mitchell Journal: Calcif Tissue Int Date: 2007-04-13 Impact factor: 4.333
Authors: S Pelletier; C B Confavreux; J Haesebaert; F Guebre-Egziabher; J Bacchetta; M-C Carlier; L Chardon; M Laville; R Chapurlat; G M London; M-H Lafage-Proust; D Fouque Journal: Osteoporos Int Date: 2015-04-25 Impact factor: 4.507
Authors: Jesper Hjortnaes; Jonathan Butcher; Jose-Luiz Figueiredo; Mark Riccio; Rainer H Kohler; Kenneth M Kozloff; Ralph Weissleder; Elena Aikawa Journal: Eur Heart J Date: 2010-07-02 Impact factor: 29.983
Authors: Sian M Robinson; Karen A Jameson; Sue F Batelaan; Helen J Martin; Holly E Syddall; Elaine M Dennison; Cyrus Cooper; Avan Aihie Sayer Journal: J Am Geriatr Soc Date: 2007-11-15 Impact factor: 5.562
Authors: Joseph A Hyder; Matthew A Allison; Nathan Wong; Agnes Papa; Thomas F Lang; Claude Sirlin; Susan M Gapstur; Pamela Ouyang; J Jeffrey Carr; Michael H Criqui Journal: Am J Epidemiol Date: 2008-12-08 Impact factor: 4.897
Authors: Ayse Zengin; Cat Shore-Lorenti; Marc Sim; Louise Maple-Brown; Sharon Lee Brennan-Olsen; Joshua R Lewis; Jennifer Ockwell; Troy Walker; David Scott; Peter Ebeling Journal: BMJ Open Date: 2022-04-04 Impact factor: 2.692
Authors: Jack Dalla Via; Marc Sim; John T Schousboe; Douglas P Kiel; Kun Zhu; Jonathan M Hodgson; Abadi K Gebre; Robin M Daly; Richard L Prince; Joshua R Lewis Journal: Calcif Tissue Int Date: 2022-08-13 Impact factor: 4.000