UNLABELLED: In this prospective study, we found a positive relationship between the prevalence of aortic calcifications and age. Aortic calcifications at baseline were positively associated with osteoporotic fractures. In addition, progression of aortic calcifications was also positively associated with the rate of decline in BMD at lumbar spine. INTRODUCTION: The aim of this study was to analyze the relationship between the progression of abdominal aortic calcification and osteoporosis in a Spanish cohort of men and women older than 50. METHODS: Men and women (n=624) aged 50 and over underwent two lateral X-rays of thoracic and lumbar spine and a dual X-ray absorptiometry (DXA) study at lumbar spine and hip, and were followed during 4 years. Abdominal aortic calcifications were classified as absent, mild-moderate and severe. RESULTS: There was a positive relationship between the prevalence of aortic calcifications and age. In both sexes, prevalent severe aortic calcifications were positively associated with prevalent osteoporotic fractures [odds ratio (OR)=1.93 (1.02-3.65)]. The association was stronger when only vertebral fracture was considered [OR=2.45 (1.23-4.87)]. In addition, progression of aortic calcifications showed a positive association with the rate of decline in bone mineral density (BMD) at lumbar spine. CONCLUSIONS: Aortic calcifications at baseline were positively associated with osteoporotic fractures. The progression of aortic calcifications was also positively associated with the rate of decline in BMD at lumbar spine.
UNLABELLED: In this prospective study, we found a positive relationship between the prevalence of aortic calcifications and age. Aortic calcifications at baseline were positively associated with osteoporotic fractures. In addition, progression of aortic calcifications was also positively associated with the rate of decline in BMD at lumbar spine. INTRODUCTION: The aim of this study was to analyze the relationship between the progression of abdominal aortic calcification and osteoporosis in a Spanish cohort of men and women older than 50. METHODS:Men and women (n=624) aged 50 and over underwent two lateral X-rays of thoracic and lumbar spine and a dual X-ray absorptiometry (DXA) study at lumbar spine and hip, and were followed during 4 years. Abdominal aortic calcifications were classified as absent, mild-moderate and severe. RESULTS: There was a positive relationship between the prevalence of aortic calcifications and age. In both sexes, prevalent severe aortic calcifications were positively associated with prevalent osteoporotic fractures [odds ratio (OR)=1.93 (1.02-3.65)]. The association was stronger when only vertebral fracture was considered [OR=2.45 (1.23-4.87)]. In addition, progression of aortic calcifications showed a positive association with the rate of decline in bone mineral density (BMD) at lumbar spine. CONCLUSIONS:Aortic calcifications at baseline were positively associated with osteoporotic fractures. The progression of aortic calcifications was also positively associated with the rate of decline in BMD at lumbar spine.
Authors: Ghada N Farhat; Jane A Cauley; Karen A Matthews; Anne B Newman; Janet Johnston; Rachel Mackey; Daniel Edmundowicz; Kim Sutton-Tyrrell Journal: J Bone Miner Res Date: 2006-12 Impact factor: 6.741
Authors: D K Roy; T W O'Neill; J D Finn; M Lunt; A J Silman; D Felsenberg; G Armbrecht; D Banzer; L I Benevolenskaya; A Bhalla; J Bruges Armas; J B Cannata; C Cooper; J Dequeker; M N Diaz; R Eastell; O B Yershova; B Felsch; W Gowin; S Havelka; K Hoszowski; A A Ismail; I Jajic; I Janott; O Johnell; J A Kanis; G Kragl; A Lopez Vaz; R Lorenc; G Lyritis; P Masaryk; C Matthis; T Miazgowski; C Gennari; H A P Pols; G Poor; H H Raspe; D M Reid; W Reisinger; C Scheidt-Nave; J J Stepan; C J Todd; K Weber; A D Woolf; J Reeve Journal: Osteoporos Int Date: 2003-01 Impact factor: 4.507
Authors: Craig R Walsh; L Adrienne Cupples; Daniel Levy; Douglas P Kiel; Marian Hannan; Peter W F Wilson; Christopher J O'Donnell Journal: Am Heart J Date: 2002-10 Impact factor: 4.749
Authors: Jimmy J Chan; L Adrienne Cupples; Douglas P Kiel; Christopher J O'Donnell; Udo Hoffmann; Elizabeth J Samelson Journal: J Bone Miner Res Date: 2015-05-06 Impact factor: 6.741
Authors: Janina M Patsch; Martin A Zulliger; Nicolas Vilayphou; Elizabeth J Samelson; Daniel Cejka; Danielle Diarra; Gundula Berzaczy; Andrew J Burghardt; Thomas M Link; Michael Weber; Christian Loewe Journal: Bone Date: 2013-08-14 Impact factor: 4.398
Authors: J Paccou; M H Edwards; K A Ward; K A Jameson; C L Moss; N C Harvey; E M Dennison; C Cooper Journal: Osteoporos Int Date: 2015-04-24 Impact factor: 4.507
Authors: D Tuñón-Le Poultel; J B Cannata-Andía; P Román-García; J B Díaz-López; E Coto; C Gómez; M Naves-Díaz; I Rodríguez Journal: Osteoporos Int Date: 2013-11-27 Impact factor: 4.507
Authors: Minerva Rodríguez-García; Carlos Gómez-Alonso; Manuel Naves-Díaz; Jose Bernardino Diaz-Lopez; Carmen Diaz-Corte; Jorge B Cannata-Andía Journal: Nephrol Dial Transplant Date: 2008-08-25 Impact factor: 5.992