Anne Orholm Nielsen1, Sadaf Qayum1, Pierre Nourdine Bouchelouche1, Lars Christian Laursen2, Ronald Dahl3, Morten Dahl4. 1. Department of Clinical Biochemistry, Zealand University Hospital, Køge, Denmark. 2. Department of Medicine, Copenhagen University Hospital, Herlev, Denmark. 3. Department of Respiratory Medicine, Odense University Hospital, Denmark. 4. Department of Clinical Biochemistry, Zealand University Hospital, Køge, Denmark. Electronic address: modah@regionsjaelland.dk.
Abstract
BACKGROUND: Patients with cystic fibrosis (CF) have a higher prevalence of asthma than the background population, however, it is unclear whether heterozygous CF carriers are susceptible to asthma. Given this, a meta-analysis is necessary to determine the veracity of the association of CF heterozygosity with asthma. METHODS: We screened the medical literature from 1966 to 2015 and performed a meta-analysis to determine the risk of asthma in CF heterozygotes vs. non-carriers. RESULTS: Aggregating data from 15 studies, the odds ratio for asthma in CF heterozygotes compared with non-carriers was significantly elevated at 1.61 (95% CI: 1.18-2.21). When analyzing the studies considered of high quality in which asthma was diagnosed by a physician, the patients were >18years, or study size was ≥500, the trend remained the same, that heterozygous carriers of CF had elevated risk for asthma. CONCLUSIONS: The results show that heterozygous carriers for CF have a higher risk of asthma than non-carriers.
BACKGROUND:Patients with cystic fibrosis (CF) have a higher prevalence of asthma than the background population, however, it is unclear whether heterozygous CF carriers are susceptible to asthma. Given this, a meta-analysis is necessary to determine the veracity of the association of CF heterozygosity with asthma. METHODS: We screened the medical literature from 1966 to 2015 and performed a meta-analysis to determine the risk of asthma in CF heterozygotes vs. non-carriers. RESULTS: Aggregating data from 15 studies, the odds ratio for asthma in CF heterozygotes compared with non-carriers was significantly elevated at 1.61 (95% CI: 1.18-2.21). When analyzing the studies considered of high quality in which asthma was diagnosed by a physician, the patients were >18years, or study size was ≥500, the trend remained the same, that heterozygous carriers of CF had elevated risk for asthma. CONCLUSIONS: The results show that heterozygous carriers for CF have a higher risk of asthma than non-carriers.
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