| Literature DB >> 27322543 |
Padhraig Gormley1,2,3,4, Verneri Anttila2,3,5, Bendik S Winsvold6,7,8, Priit Palta9, Tonu Esko2,10,11, Tune H Pers2,11,12,13, Kai-How Farh2,5,14, Ester Cuenca-Leon1,2,3,15, Mikko Muona9,16,17,18, Nicholas A Furlotte19, Tobias Kurth20,21, Andres Ingason22, George McMahon23, Lannie Ligthart24, Gisela M Terwindt25, Mikko Kallela26, Tobias M Freilinger27,28, Caroline Ran29, Scott G Gordon30, Anine H Stam25, Stacy Steinberg22, Guntram Borck31, Markku Koiranen32, Lydia Quaye33, Hieab H H Adams34,35, Terho Lehtimäki36, Antti-Pekka Sarin9, Juho Wedenoja37, David A Hinds19, Julie E Buring21,38, Markus Schürks39, Paul M Ridker21,38, Maria Gudlaug Hrafnsdottir40, Hreinn Stefansson22, Susan M Ring23, Jouke-Jan Hottenga24, Brenda W J H Penninx41, Markus Färkkilä26, Ville Artto26, Mari Kaunisto9, Salli Vepsäläinen26, Rainer Malik28, Andrew C Heath42, Pamela A F Madden42, Nicholas G Martin30, Grant W Montgomery30, Mitja I Kurki1,2,3,9,43, Mart Kals10, Reedik Mägi10, Kalle Pärn10, Eija Hämäläinen9, Hailiang Huang2,3,5, Andrea E Byrnes2,3,5, Lude Franke44, Jie Huang4, Evie Stergiakouli23, Phil H Lee1,2,3, Cynthia Sandor45, Caleb Webber45, Zameel Cader46,47, Bertram Muller-Myhsok48,49,50, Stefan Schreiber51, Thomas Meitinger52,53, Johan G Eriksson54,55, Veikko Salomaa55, Kauko Heikkilä56, Elizabeth Loehrer34,57, Andre G Uitterlinden58, Albert Hofman34, Cornelia M van Duijn34, Lynn Cherkas33, Linda M Pedersen6, Audun Stubhaug59,60, Christopher S Nielsen59,61, Minna Männikkö32, Evelin Mihailov10, Lili Milani10, Hartmut Göbel62, Ann-Louise Esserlind63, Anne Francke Christensen63, Thomas Folkmann Hansen64, Thomas Werge65,66,67, Jaakko Kaprio9,37,68, Arpo J Aromaa55, Olli Raitakari69,70, M Arfan Ikram34,35,71, Tim Spector33, Marjo-Riitta Järvelin32,72,73,74, Andres Metspalu10, Christian Kubisch75, David P Strachan76, Michel D Ferrari25, Andrea C Belin29, Martin Dichgans28,49, Maija Wessman9,16, Arn M J M van den Maagdenberg25,77, John-Anker Zwart6,7,8, Dorret I Boomsma24, George Davey Smith23, Kari Stefansson22,78, Nicholas Eriksson19, Mark J Daly2,3,5, Benjamin M Neale2,3,5, Jes Olesen63, Daniel I Chasman21,38, Dale R Nyholt79, Aarno Palotie1,2,3,4,5,9,80.
Abstract
Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10(-8)) that mapped to 38 distinct genomic loci, including 28 loci not previously reported and a locus that to our knowledge is the first to be identified on chromosome X. In subsequent computational analyses, the identified loci showed enrichment for genes expressed in vascular and smooth muscle tissues, consistent with a predominant theory of migraine that highlights vascular etiologies.Entities:
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Year: 2016 PMID： 27322543 PMCID： PMC5331903 DOI： 10.1038/ng.3598
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330