Wei Wang1,2, Chunhua Xu1,2, Yuchao Wang1,2, Like Yu1,2, Xiuwei Zhang3. 1. a Endoscopic Center of Nanjing Chest Hospital , Nanjing , Jiangsu 210029 , China. 2. b Clinical Center of Nanjing Respiratory Diseases and Imaging , Nanjing , Jiangsu 210029 , China. 3. c Department of Respiratory Medicine , Nanjing Jiangning Hospital , Nanjing , Jiangsu 211100 , China.
Abstract
OBJECTIVE: The aim of this study was to explore the prognostic value of serum soluble B7-H4 (sB7-H4) levels in patients with non-small cell lung cancer (NSCLC). METHODS: Serum specimens from 316 NSCLC patients and 240 healthy controls were collected. The concentrations of sB7-H4 were measured by ELISA. RESULTS: The levels of sB7-H4 in NSCLC patients were significantly higher than that of the controls (P<0.01). Multivariate survival analysis indicated that sB7-H4 was an independent prognostic indicator of overall survival and progression-free survival (P<0.01). CONCLUSIONS: Measurement of serum sB7-H4 might be a useful prognostic biomarker for NSCLC.
OBJECTIVE: The aim of this study was to explore the prognostic value of serum soluble B7-H4 (sB7-H4) levels in patients with non-small cell lung cancer (NSCLC). METHODS: Serum specimens from 316 NSCLCpatients and 240 healthy controls were collected. The concentrations of sB7-H4 were measured by ELISA. RESULTS: The levels of sB7-H4 in NSCLCpatients were significantly higher than that of the controls (P<0.01). Multivariate survival analysis indicated that sB7-H4 was an independent prognostic indicator of overall survival and progression-free survival (P<0.01). CONCLUSIONS: Measurement of serum sB7-H4 might be a useful prognostic biomarker for NSCLC.