| Literature DB >> 27319430 |
Chukwuemeka N Okafor1, Natalie E Kelso1, Vaughn Bryant2, Larry E Burrell2, Maria Jose Míguez3, Assawin Gongvatana4, Karen T Tashima5, Suzanne de la Monte5, Robert L Cook1, Ronald A Cohen6.
Abstract
To determine the relationships among body mass index (BMI), and HIV-associated neurocognitive impairment and the potential mediating effects of inflammatory cytokines. Among the HIV-infected individuals (N = 90) included in this study, obesity was associated with slower processing speed (β = -.229, standard error (SE) = 2.15, p = .033), compared to participants with a normal BMI, after controlling for psychosocial and HIV clinical factors. Serum concentrations of the interleukin-16 (IL-16) cytokine were significantly associated with slowed processing speed (β = -.235, SE = 1.62, p = .033) but did not mediate the relationship between obesity and processing speed These findings suggest that obesity may contribute to cognitive processing speed deficits in HIV-infected adults. Elevated concentrations of IL-16 are also associated with slowing, though the results suggest that obesity and IL-16 may exert independent effects.Entities:
Keywords: HIV; body mass index; cytokines; inflammation; neurocognition
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Year: 2016 PMID： 27319430 PMCID： PMC5173436 DOI： 10.1080/13548506.2016.1199887
Source DB: PubMed Journal: Psychol Health Med ISSN： 1354-8506 Impact factor: 2.423