Literature DB >> 2731591

Acute pancreatitis and bile duct lesions in rat induced by dibutyltin dichloride.

J Merkord1, G Hennighausen.   

Abstract

After i.v. or i.p. administration of a single dose of dibutyltin dichloride (DBTC) the following changes were observed in pancreas and bile ducts of male rats: acute interstitial pancreatitis, enlargement of diameter and destruction of epithelial cells of the bile ducts, increase of serum alkaline phosphatase activity. The effects were dependent on the dose of DBTC (1, 4 or 6 mg/kg body weight), the route of administration and the time after treatment. The pancreatitis induced by DBTC is under further investigation as a model of experimental pancreatitis.

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Year:  1989        PMID： 2731591     DOI： 10.1016/s0232-1513(89)80113-6

Source DB:  PubMed          Journal:  Exp Pathol        ISSN： 0232-1513


  6 in total

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4.  Animal models of chronic pancreatitis.

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5.  Dibutyltin disrupts glucocorticoid receptor function and impairs glucocorticoid-induced suppression of cytokine production.

Authors:  Christel Gumy; Charlie Chandsawangbhuwana; Anna A Dzyakanchuk; Denise V Kratschmar; Michael E Baker; Alex Odermatt
Journal:  PLoS One       Date:  2008-10-28       Impact factor: 3.240

6.  Influence of daily oral prophylactic selenium treatment on the dibutyltin dichloride (DBTC)-induced pancreatitis in rats.

Authors:  J Merkord; N Görl; M Lemke; A Berg; H Weber; R Ramer; G Hennighausen
Journal:  EXCLI J       Date:  2017-02-16       Impact factor: 4.068
  6 in total

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