Literature DB >> 27314093

The mevalonate pathway as a metabolic requirement for autophagy-implications for growth control, proteostasis, and disease.

Teemu P Miettinen1, Mikael Björklund1.   

Abstract

Autophagy is responsible for the degradation and recycling of cellular proteins and organelles. Our recent work shows that the mevalonate pathway influences cell size, growth, and proteostasis by regulating basal autophagic flux through geranylgeranylation of the small GTPase RAB11. The control of autophagy by the mevalonate/cholesterol pathway has potential implications for statin toxicity, inflammation, cancer, and neurodegenerative diseases.

Entities:  

Keywords:  Autophagy; RAB11; cancer; cell size control; inflammation; mevalonate pathway; myopathy; proteostasis; senescence; statins

Year:  2016        PMID： 27314093      PMCID： PMC4909433          DOI： 10.1080/23723556.2016.1143546

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

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5.  Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle.

Authors:  Peixiang Zhang; M Anthony Verity; Karen Reue
Journal:  Cell Metab       Date:  2014-06-12       Impact factor: 27.287

Review 6.  Mevalonate kinase deficiency, a metabolic autoinflammatory disease.

Authors:  Robert van der Burgh; Nienke M Ter Haar; Marianne L Boes; Joost Frenkel
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Journal:  Nature       Date:  2016-01-07       Impact factor: 49.962

8.  Identification of transcriptional and metabolic programs related to mammalian cell size.

Authors:  Teemu P Miettinen; Heli K J Pessa; Matias J Caldez; Tobias Fuhrer; M Kasim Diril; Uwe Sauer; Philipp Kaldis; Mikael Björklund
Journal:  Curr Biol       Date:  2014-03-06       Impact factor: 10.834

9.  Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization.

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10.  Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy.

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  10 in total
  11 in total

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6.  Statin and Bisphosphonate Induce Starvation in Fast-Growing Cancer Cell Lines.

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Review 7.  The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors.

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9.  Incomplete mitophagy in the mevalonate kinase-deficient Saccharomyces cerevisiae and its relation to the MKD-related autoinflammatory disease in humans.

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Review 10.  Autophagy Modulators in Cancer Therapy.

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