Literature DB >> 27314090

Drosophila Aurora A regulates mitotic timing in cancer stem cells: Possible therapeutic implications.

Renaud Caous1, Laurent Richard-Parpaillon1, Régis Giet1.   

Abstract

Loss of Aurora A in Drosophila neuroblasts promotes loss of cell fate, leading to brain tumors. We showed that these tumor stem cells are delayed during mitosis and efficiently segregate their chromosomes even without the spindle assembly checkpoint. Here, we discuss the possible relevance of our results to human cancers.

Entities:  

Keywords:  Aneuploidy; Aurora A kinase; Spindle Assembly Checkpoint; stem cell; tumour

Year:  2016        PMID： 27314090      PMCID： PMC4909412          DOI： 10.1080/23723556.2016.1140261

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics.

Authors:  Andrea Musacchio
Journal:  Curr Biol       Date:  2015-10-19       Impact factor: 10.834

2.  Recruitment of Mad2 to the kinetochore requires the Rod/Zw10 complex.

Authors:  Eulalie Buffin; Christophe Lefebvre; Junyong Huang; Mary Elisabeth Gagou; Roger E Karess
Journal:  Curr Biol       Date:  2005-05-10       Impact factor: 10.834

3.  Flies without centrioles.

Authors:  Renata Basto; Joyce Lau; Tatiana Vinogradova; Alejandra Gardiol; C Geoffrey Woods; Alexey Khodjakov; Jordan W Raff
Journal:  Cell       Date:  2006-06-30       Impact factor: 41.582

4.  Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles.

Authors:  D M Glover; M H Leibowitz; D A McLean; H Parry
Journal:  Cell       Date:  1995-04-07       Impact factor: 41.582

Review 5.  Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics.

Authors:  Cayetano Gonzalez
Journal:  Nat Rev Cancer       Date:  2013-02-07       Impact factor: 60.716

Review 6.  How do anti-mitotic drugs kill cancer cells?

Authors:  Karen E Gascoigne; Stephen S Taylor
Journal:  J Cell Sci       Date:  2009-08-01       Impact factor: 5.285

Review 7.  Targeting Mitosis in Cancer: Emerging Strategies.

Authors:  Carmen Dominguez-Brauer; Kelsie L Thu; Jacqueline M Mason; Heiko Blaser; Mark R Bray; Tak W Mak
Journal:  Mol Cell       Date:  2015-11-19       Impact factor: 17.970

Review 8.  Asymmetric cell division: recent developments and their implications for tumour biology.

Authors:  Juergen A Knoblich
Journal:  Nat Rev Mol Cell Biol       Date:  2010-12       Impact factor: 94.444

9.  Aneuploidy causes premature differentiation of neural and intestinal stem cells.

Authors:  Delphine Gogendeau; Katarzyna Siudeja; Davide Gambarotto; Carole Pennetier; Allison J Bardin; Renata Basto
Journal:  Nat Commun       Date:  2015-11-17       Impact factor: 14.919

10.  Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila.

Authors:  Renaud Caous; Aude Pascal; Pierre Romé; Laurent Richard-Parpaillon; Roger Karess; Régis Giet
Journal:  Nat Commun       Date:  2015-11-16       Impact factor: 14.919
  10 in total
  1 in total

Review 1.  Chromosome integrity checkpoints in stem and progenitor cells: transitions upon differentiation, pathogenesis, and aging.

Authors:  Andreas Brown; Hartmut Geiger
Journal:  Cell Mol Life Sci       Date:  2018-07-31       Impact factor: 9.261
  1 in total

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