Literature DB >> 27314081

The CDC20-APC/SOX2 signaling axis: An achilles' heel for glioblastoma.

Amit D Gujar1, Hiroko Yano2, Albert H Kim3.   

Abstract

Glioblastoma stem-like cells (GSCs) play a critical role in glioblastoma progression and recurrence. We discuss recent results on the role of the mitotic ubiquitin ligase cell division cycle 20-anaphase-promoting complex (CDC20-APC) in the governance of cardinal GSC functions through a mechanism involving the transcription factor sex-determining region Y-box 2 (SOX2). These findings expand the non-mitotic roles of CDC20-APC with implications for stem cell biology.

Entities:  

Keywords:  CDC20; CDC20–anaphase-promoting complex; Cancer stem cells; SOX2; glioblastoma; glioblastoma stem-like cells; in vivo tumorigenicity; invasion; self-renewal; tumor-initiating cells

Year:  2015        PMID： 27314081      PMCID： PMC4909416          DOI： 10.1080/23723556.2015.1075644

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Post-translational modulation of pluripotency.

Authors:  Ning Cai; Mo Li; Jing Qu; Guang-Hui Liu; Juan Carlos Izpisua Belmonte
Journal:  J Mol Cell Biol       Date:  2012-06-07       Impact factor: 6.216

Review 2.  Targeting Cdc20 as a novel cancer therapeutic strategy.

Authors:  Lixia Wang; Jinfang Zhang; Lixin Wan; Xiuxia Zhou; Zhiwei Wang; Wenyi Wei
Journal:  Pharmacol Ther       Date:  2015-04-04       Impact factor: 12.310

3.  Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

Authors:  Shideng Bao; Qiulian Wu; Roger E McLendon; Yueling Hao; Qing Shi; Anita B Hjelmeland; Mark W Dewhirst; Darell D Bigner; Jeremy N Rich
Journal:  Nature       Date:  2006-10-18       Impact factor: 49.962

Review 4.  Molecular and cellular heterogeneity: the hallmark of glioblastoma.

Authors:  Diane J Aum; David H Kim; Thomas L Beaumont; Eric C Leuthardt; Gavin P Dunn; Albert H Kim
Journal:  Neurosurg Focus       Date:  2014-12       Impact factor: 4.047

5.  Elevated invasive potential of glioblastoma stem cells.

Authors:  Lin Cheng; Qiulian Wu; Olga A Guryanova; Zhi Huang; Qian Huang; Jeremy N Rich; Shideng Bao
Journal:  Biochem Biophys Res Commun       Date:  2011-03-01       Impact factor: 3.575

6.  A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells.

Authors:  Diane D Mao; Amit D Gujar; Tatenda Mahlokozera; Ishita Chen; Yanchun Pan; Jingqin Luo; Taylor Brost; Elizabeth A Thompson; Alice Turski; Eric C Leuthardt; Gavin P Dunn; Michael R Chicoine; Keith M Rich; Joshua L Dowling; Gregory J Zipfel; Ralph G Dacey; Samuel Achilefu; David D Tran; Hiroko Yano; Albert H Kim
Journal:  Cell Rep       Date:  2015-06-11       Impact factor: 9.423

7.  A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons.

Authors:  Albert H Kim; Sidharth V Puram; Parizad M Bilimoria; Yoshiho Ikeuchi; Samantha Keough; Michael Wong; David Rowitch; Azad Bonni
Journal:  Cell       Date:  2009-01-23       Impact factor: 41.582

8.  Identification of human brain tumour initiating cells.

Authors:  Sheila K Singh; Cynthia Hawkins; Ian D Clarke; Jeremy A Squire; Jane Bayani; Takuichiro Hide; R Mark Henkelman; Michael D Cusimano; Peter B Dirks
Journal:  Nature       Date:  2004-11-18       Impact factor: 49.962

9.  CDC20 maintains tumor initiating cells.

Authors:  Qi Xie; Qiulian Wu; Stephen C Mack; Kailin Yang; Leo Kim; Christopher G Hubert; William A Flavahan; Chengwei Chu; Shideng Bao; Jeremy N Rich
Journal:  Oncotarget       Date:  2015-05-30

10.  A restricted cell population propagates glioblastoma growth after chemotherapy.

Authors:  Jian Chen; Yanjiao Li; Tzong-Shiue Yu; Renée M McKay; Dennis K Burns; Steven G Kernie; Luis F Parada
Journal:  Nature       Date:  2012-08-23       Impact factor: 49.962
  10 in total
  4 in total

Review 1.  APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis.

Authors:  Morgan S Schrock; Benjamin R Stromberg; Luke Scarberry; Matthew K Summers
Journal:  Semin Cancer Biol       Date:  2020-03-09       Impact factor: 15.707

Review 2.  Genes of the Ubiquitin Proteasome System Qualify as Differential Markers in Malignant Glioma of Astrocytic and Oligodendroglial Origin.

Authors:  Jerry Vriend; Thomas Klonisch
Journal:  Cell Mol Neurobiol       Date:  2022-07-27       Impact factor: 4.231

3.  CDC20 is a novel biomarker for improved clinical predictions in epithelial ovarian cancer.

Authors:  Xiaoxue Xi; Tianyue Cao; Yonghong Qian; Huiling Wang; Songwen Ju; Youguo Chen; Ting Chen; Jian Yang; Biaoquan Liang; Shunyu Hou
Journal:  Am J Cancer Res       Date:  2022-07-15       Impact factor: 5.942

4.  Identification of prognostic markers by weighted gene co-expression network analysis in non-small cell lung cancer.

Authors:  Binglin Chen; Xiaowei Xie; Feifeng Lan; Wenqi Liu
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269
  4 in total

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