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Literature DB >> 32165320

APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis.

Morgan S Schrock¹, Benjamin R Stromberg¹, Luke Scarberry¹, Matthew K Summers².

Abstract

The anaphase promoting complex/ cyclosome (APC/C), is an evolutionarily conserved protein complex essential for cellular division due to its role in regulating the mitotic transition from metaphase to anaphase. In this review, we highlight recent work that has shed light on our understanding of the role of APC/C coactivators, Cdh1 and Cdc20, in cancer initiation and development. We summarize the current state of knowledge regarding APC/C structure and function, as well as the distinct ways Cdh1 and Cdc20 are dysregulated in human cancer. We also discuss APC/C inhibitors, novel approaches for targeting the APC/C as a cancer therapy, and areas for future work.

Entities: Disease Gene Species

Keywords: Anaphase promoting complex/ cyclosome; Cancer; Cdc20; Cdh1; Genome instability

Year: 2020 PMID： 32165320 PMCID： PMC7483777 DOI： 10.1016/j.semcancer.2020.03.001

Source DB: PubMed Journal: Semin Cancer Biol ISSN： 1044-579X Impact factor: 15.707

189 in total

1. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20.

Authors: X Luo; G Fang; M Coldiron; Y Lin; H Yu; M W Kirschner; G Wagner
Journal: Nat Struct Biol Date: 2000-03

2. Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.

Authors: L Sironi; M Melixetian; M Faretta; E Prosperini; K Helin; A Musacchio
Journal: EMBO J Date: 2001-11-15 Impact factor: 11.598

3. Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element.

Authors: Surajit Sinha; Sunil Kumar Malonia; Smriti P K Mittal; Kamini Singh; Sreenath Kadreppa; Rohan Kamat; Robin Mukhopadhyaya; Jayanta K Pal; Samit Chattopadhyay
Journal: EMBO J Date: 2010-01-14 Impact factor: 11.598

4. Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex.

Authors: C Lukas; C S Sørensen; E Kramer; E Santoni-Rugiu; C Lindeneg; J M Peters; J Bartek; J Lukas
Journal: Nature Date: 1999-10-21 Impact factor: 49.962

5. F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress.

Authors: Sunil K Malonia; Parul Dutta; Manas Kumar Santra; Michael R Green
Journal: Proc Natl Acad Sci U S A Date: 2015-06-29 Impact factor: 11.205

6. Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae.

Authors: Luigi Nezi; Giulia Rancati; Anna De Antoni; Sebastiano Pasqualato; Simonetta Piatti; Andrea Musacchio
Journal: J Cell Biol Date: 2006-07-03 Impact factor: 10.539

7. APC/C^FZR-1 Controls SAS-5 Levels To Regulate Centrosome Duplication in Caenorhabditis elegans.

Authors: Jeffrey C Medley; Lauren E DeMeyer; Megan M Kabara; Mi Hye Song
Journal: G3 (Bethesda) Date: 2017-12-04 Impact factor: 3.154

8. CDC20 contributes to the development of human cutaneous squamous cell carcinoma through the Wnt/β‑catenin signaling pathway.

Authors: Zhaowei Chu; Xinyue Zhang; Qingyan Li; Guanglei Hu; Christine Guo Lian; Songmei Geng
Journal: Int J Oncol Date: 2019-02-27 Impact factor: 5.650

9. UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit.

Authors: Mathew J Garnett; Jörg Mansfeld; Colin Godwin; Takahiro Matsusaka; Jiahua Wu; Paul Russell; Jonathon Pines; Ashok R Venkitaraman
Journal: Nat Cell Biol Date: 2009-10-11 Impact factor: 28.824

Review 10. Panta rhei: the APC/C at steady state.

Authors: Ivana Primorac; Andrea Musacchio
Journal: J Cell Biol Date: 2013-04-15 Impact factor: 10.539

17 in total

1. A review on cullin neddylation and strategies to identify its inhibitors for cancer therapy.

Authors: Iqra Bano; Moolchand Malhi; Min Zhao; Liviu Giurgiulescu; Hira Sajjad; Marek Kieliszek
Journal: 3 Biotech Date: 2022-03-29 Impact factor: 2.406

2. Design, Synthesis, and Biological Evaluation of Apcin-Based CDC20 Inhibitors.

Authors: Rajib Bhuniya; Xinrui Yuan; Longchuan Bai; Kathryn L Howie; Rui Wang; Wei Li; Frank Park; Chao-Yie Yang
Journal: ACS Med Chem Lett Date: 2022-01-18 Impact factor: 4.345

3. CDC20 is a novel biomarker for improved clinical predictions in epithelial ovarian cancer.

Authors: Xiaoxue Xi; Tianyue Cao; Yonghong Qian; Huiling Wang; Songwen Ju; Youguo Chen; Ting Chen; Jian Yang; Biaoquan Liang; Shunyu Hou
Journal: Am J Cancer Res Date: 2022-07-15 Impact factor: 5.942

4. The Expression and Role Analysis of Methylation-Regulated Differentially Expressed Gene UBE2C in Pan-Cancer, Especially for HGSOC.

Authors: Jiajia Li; Yating Sun; Xiuling Zhi; Qin Li; Liangqing Yao; Mo Chen
Journal: Cancers (Basel) Date: 2022-06-25 Impact factor: 6.575

Review 5. The Role of the APC/C and Its Coactivators Cdh1 and Cdc20 in Cancer Development and Therapy.

Authors: Christine Greil; Monika Engelhardt; Ralph Wäsch
Journal: Front Genet Date: 2022-06-27 Impact factor: 4.772

6. The bioinformatics and experimental analysis of the novel roles of virus infection-associated gene CDC20 for prognosis and immune infiltration in hepatocellular carcinoma.

Authors: Juanni Li; Xiaofang Zhang; Lei Yao; Kuan Hu
Journal: Aging (Albany NY) Date: 2022-05-27 Impact factor: 5.955