Literature DB >> 27314078

Novel insights into the mechanisms of mitotic spindle assembly by NEK kinases.

Suzanna L Prosser1, Laura O'Regan2, Andrew M Fry2.   

Abstract

The mitotic spindle is the apparatus upon which chromosomes are segregated during cell division. We have discovered new roles for two members of the NIMA-related kinase (NEK) family in different molecular processes of spindle assembly. Moreover, loss of these proteins leads to segregation errors that drive cancer progression.

Entities:  

Keywords:  Centrosome separation; Hsp72; Nek5; Nek6; mitosis; spindle assembly

Year:  2015        PMID： 27314078      PMCID： PMC4909405          DOI： 10.1080/23723556.2015.1062952

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.

Authors:  Laura O'Regan; Andrew M Fry
Journal:  Mol Cell Biol       Date:  2009-05-04       Impact factor: 4.272

2.  The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis.

Authors:  Min-Jean Yin; Lihua Shao; David Voehringer; Tod Smeal; Bahija Jallal
Journal:  J Biol Chem       Date:  2003-10-16       Impact factor: 5.157

Review 3.  Amorphous no more: subdiffraction view of the pericentriolar material architecture.

Authors:  Vito Mennella; David A Agard; Bo Huang; Laurence Pelletier
Journal:  Trends Cell Biol       Date:  2013-11-19       Impact factor: 20.808

4.  The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation.

Authors:  Joseph Rapley; Marta Nicolàs; Aaron Groen; Laura Regué; M Teresa Bertran; Carme Caelles; Joseph Avruch; Joan Roig
Journal:  J Cell Sci       Date:  2008-11-11       Impact factor: 5.285

5.  Timing of centrosome separation is important for accurate chromosome segregation.

Authors:  William T Silkworth; Isaac K Nardi; Raja Paul; Alex Mogilner; Daniela Cimini
Journal:  Mol Biol Cell       Date:  2011-11-30       Impact factor: 4.138

6.  Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis.

Authors:  Suzanna L Prosser; Navdeep K Sahota; Laurence Pelletier; Ciaran G Morrison; Andrew M Fry
Journal:  J Cell Biol       Date:  2015-05-11       Impact factor: 10.539

7.  Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.

Authors:  Laura O'Regan; Josephina Sampson; Mark W Richards; Axel Knebel; Daniel Roth; Fiona E Hood; Anne Straube; Stephen J Royle; Richard Bayliss; Andrew M Fry
Journal:  J Cell Biol       Date:  2015-05-04       Impact factor: 10.539

Review 8.  Cell cycle regulation by the NEK family of protein kinases.

Authors:  Andrew M Fry; Laura O'Regan; Sarah R Sabir; Richard Bayliss
Journal:  J Cell Sci       Date:  2012-11-06       Impact factor: 5.285

9.  Examining the link between chromosomal instability and aneuploidy in human cells.

Authors:  Sarah L Thompson; Duane A Compton
Journal:  J Cell Biol       Date:  2008-02-18       Impact factor: 10.539

10.  Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction.

Authors:  Tara Hardy; Miseon Lee; Rebecca S Hames; Suzanna L Prosser; Donna-Marie Cheary; Mugdha D Samant; Francisca Schultz; Joanne E Baxter; Kunsoo Rhee; Andrew M Fry
Journal:  J Cell Sci       Date:  2014-04-02       Impact factor: 5.285
  10 in total
  8 in total

1.  Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release.

Authors:  Manjeet Mukherjee; Sarah Sabir; Laura O'Regan; Josephina Sampson; Mark W Richards; Nicolas Huguenin-Dezot; James R Ault; Jason W Chin; Anastasia Zhuravleva; Andrew M Fry; Richard Bayliss
Journal:  Sci Signal       Date:  2018-08-14       Impact factor: 8.192

2.  NEK8 regulates DNA damage-induced RAD51 foci formation and replication fork protection.

Authors:  Antonio Abeyta; Maria Castella; Celine Jacquemont; Toshiyasu Taniguchi
Journal:  Cell Cycle       Date:  2016-11-28       Impact factor: 4.534

3.  Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer.

Authors:  Tie Xu; Yulan Zeng; Linli Shi; Qin Yang; Yeshan Chen; Gang Wu; Guiling Li; Shuangbing Xu
Journal:  J Exp Clin Cancer Res       Date:  2020-09-10

4.  Integrative Analysis of the Expression Levels and Prognostic Values for NEK Family Members in Breast Cancer.

Authors:  Wen-Liang Gao; Lei Niu; Wei-Ling Chen; Yong-Qu Zhang; Wen-He Huang
Journal:  Front Genet       Date:  2022-03-16       Impact factor: 4.599

Review 5.  In Mitosis You Are Not: The NIMA Family of Kinases in Aspergillus, Yeast, and Mammals.

Authors:  Scott Bachus; Drayson Graves; Lauren Fulham; Nikolas Akkerman; Caelan Stephanson; Jessica Shieh; Peter Pelka
Journal:  Int J Mol Sci       Date:  2022-04-06       Impact factor: 5.923

6.  NEK2 Serves as a Novel Biomarker and Enhances the Tumorigenicity of Clear-CellRenal-Cell Carcinoma by Activating WNT/β-Catenin Pathway.

Authors:  Jiancheng Zhou; Jiawei Lai; Yongyi Cheng; Weixing Qu
Journal:  Evid Based Complement Alternat Med       Date:  2022-09-29       Impact factor: 2.650

7.  Never-in-mitosis A-related kinase 8, a novel target of von-Hippel-Lindau tumor suppressor protein, promotes gastric cancer cell proliferation.

Authors:  Xiao-Fei Ding; Jie Chen; Jun Zhou; Guang Chen; Ying-Liang Wu
Journal:  Oncol Lett       Date:  2018-08-20       Impact factor: 2.967

8.  Bioinformatics analysis of the prognostic value of NEK8 and its effects on immune cell infiltration in glioma.

Authors:  Meng Xiao; Chaoyang Du; Chuanbo Zhang; Xinzhong Zhang; Shaomin Li; Dainan Zhang; Wang Jia
Journal:  J Cell Mol Med       Date:  2021-08-10       Impact factor: 5.310
  8 in total

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