Literature DB >> 27314077

p32: A new player in autophagy.

Haifeng Jiao1, Han You1.   

Abstract

Unc-51 like kinase-1 (Ulk1) is essential for autophagy induction. We recently reported that p32/C1QBP is crucial for the induction of autophagic flux upon starvation and the clearance of damaged mitochondria through the regulation of Ulk1 stability and kinase activity. Our results underscore the importance of p32 in fine-tuning the stress response and mitochondrial homeostasis via Ulk1.

Entities:  

Keywords:  Autophagy; p32; ULK1

Year:  2015        PMID： 27314077      PMCID： PMC4909465          DOI： 10.1080/23723556.2015.1061097

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Chaperone-like protein p32 regulates ULK1 stability and autophagy.

Authors:  H Jiao; G-Q Su; W Dong; L Zhang; W Xie; L-M Yao; P Chen; Z-X Wang; Y-C Liou; H You
Journal:  Cell Death Differ       Date:  2015-04-23       Impact factor: 15.828

2.  Metabolism: Putting energy into mitophagy.

Authors:  Katharine H Wrighton
Journal:  Nat Rev Mol Cell Biol       Date:  2013-05-09       Impact factor: 94.444

3.  ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy.

Authors:  Wenxian Wu; Weili Tian; Zhe Hu; Guo Chen; Lei Huang; Wen Li; Xingli Zhang; Peng Xue; Changqian Zhou; Lei Liu; Yushan Zhu; Xingliang Zhang; Longxuan Li; Liangqing Zhang; Senfang Sui; Bin Zhao; Du Feng
Journal:  EMBO Rep       Date:  2014-03-26       Impact factor: 8.807

4.  Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy.

Authors:  Joung Hyuck Joo; Frank C Dorsey; Aashish Joshi; Kristin M Hennessy-Walters; Kristie L Rose; Kelly McCastlain; Ji Zhang; Rekha Iyengar; Chang Hwa Jung; Der-Fen Suen; Meredith A Steeves; Chia-Ying Yang; Stephanie M Prater; Do-Hyung Kim; Craig B Thompson; Richard J Youle; Paul A Ney; John L Cleveland; Mondira Kundu
Journal:  Mol Cell       Date:  2011-08-19       Impact factor: 17.970

5.  AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.

Authors:  Joungmok Kim; Mondira Kundu; Benoit Viollet; Kun-Liang Guan
Journal:  Nat Cell Biol       Date:  2011-01-23       Impact factor: 28.824

6.  mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.

Authors:  Francesca Nazio; Flavie Strappazzon; Manuela Antonioli; Pamela Bielli; Valentina Cianfanelli; Matteo Bordi; Christine Gretzmeier; Joern Dengjel; Mauro Piacentini; Gian Maria Fimia; Francesco Cecconi
Journal:  Nat Cell Biol       Date:  2013-03-24       Impact factor: 28.824

7.  Mitochondrial p32 is a critical mediator of ARF-induced apoptosis.

Authors:  Koji Itahana; Yanping Zhang
Journal:  Cancer Cell       Date:  2008-06       Impact factor: 31.743

8.  Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation.

Authors:  Valentina Fogal; Adam D Richardson; Priya P Karmali; Immo E Scheffler; Jeffrey W Smith; Erkki Ruoslahti
Journal:  Mol Cell Biol       Date:  2010-01-25       Impact factor: 4.272

9.  Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

Authors:  Daniel F Egan; David B Shackelford; Maria M Mihaylova; Sara Gelino; Rebecca A Kohnz; William Mair; Debbie S Vasquez; Aashish Joshi; Dana M Gwinn; Rebecca Taylor; John M Asara; James Fitzpatrick; Andrew Dillin; Benoit Viollet; Mondira Kundu; Malene Hansen; Reuben J Shaw
Journal:  Science       Date:  2010-12-23       Impact factor: 47.728

Review 10.  Autophagy in the pathogenesis of disease.

Authors:  Beth Levine; Guido Kroemer
Journal:  Cell       Date:  2008-01-11       Impact factor: 41.582
  10 in total
  3 in total

1.  Leaked Mitochondrial C1QBP Inhibits Activation of the DNA Sensor cGAS.

Authors:  Kun Song; Yakun Wu; Bishi Fu; Lingyan Wang; Wenzhuo Hao; Fang Hua; Yiwen Sun; Martin E Dorf; Shitao Li
Journal:  J Immunol       Date:  2021-09-15       Impact factor: 5.426

2.  The Mitochondrial Protein C1QBP Promotes Hepatocellular Carcinoma Progression by Enhancing Cell Survival, Migration and Invasion.

Authors:  Guoxin Hou; Zhimin Lu; Zhen Wang; Xinmei Yang
Journal:  J Cancer       Date:  2022-05-09       Impact factor: 4.478

3.  C9-ALS-Associated Proline-Arginine Dipeptide Repeat Protein Induces Activation of NLRP3 Inflammasome of HMC3 Microglia Cells by Binding of Complement Component 1 Q Subcomponent-Binding Protein (C1QBP), and Syringin Prevents This Effect.

Authors:  Ru-Huei Fu; Chia-Wen Tsai; Shao-Chih Chiu; Shih-Ping Liu; Yu-Ting Chiang; Yun-Hua Kuo; Woei-Cherng Shyu; Shinn-Zong Lin
Journal:  Cells       Date:  2022-10-05       Impact factor: 7.666
  3 in total

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