Literature DB >> 27313072

Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes?

Sevim Kahraman1, Erin R Okawa1,2, Rohit N Kulkarni3,4.   

Abstract

Diabetes is a progressive disease affecting millions of people worldwide. There are several medications and treatment options to improve the life quality of people with diabetes. One of the strategies for the treatment of diabetes could be the use of human pluripotent stem cells or induced pluripotent stem cells. The recent advances in differentiation of stem cells into insulin-secreting beta-like cells in vitro make the transplantation of the stem cell-derived beta-like cells an attractive approach for treatment of type 1 and type 2 diabetes. While stem cell-derived beta-like cells provide an unlimited cell source for beta cell replacement therapies, these cells can also be used as a platform for drug screening or modeling diseases.

Entities:  

Keywords:  Diabetes; Differentiation; Human pluripotent stem cells; Induced pluripotent stem cells; Pancreatic beta cells

Mesh：

Year:  2016        PMID： 27313072      PMCID： PMC5877461          DOI： 10.1007/s11892-016-0764-0

Source DB:  PubMed          Journal:  Curr Diab Rep        ISSN： 1534-4827            Impact factor:   4.810


  64 in total

1.  Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.

Authors:  Benjamin M Scirica; Deepak L Bhatt; Eugene Braunwald; P Gabriel Steg; Jaime Davidson; Boaz Hirshberg; Peter Ohman; Robert Frederich; Stephen D Wiviott; Elaine B Hoffman; Matthew A Cavender; Jacob A Udell; Nihar R Desai; Ofri Mosenzon; Darren K McGuire; Kausik K Ray; Lawrence A Leiter; Itamar Raz
Journal:  N Engl J Med       Date:  2013-09-02       Impact factor: 91.245

2.  A metagenome-wide association study of gut microbiota in type 2 diabetes.

Authors:  Junjie Qin; Yingrui Li; Zhiming Cai; Shenghui Li; Jianfeng Zhu; Fan Zhang; Suisha Liang; Wenwei Zhang; Yuanlin Guan; Dongqian Shen; Yangqing Peng; Dongya Zhang; Zhuye Jie; Wenxian Wu; Youwen Qin; Wenbin Xue; Junhua Li; Lingchuan Han; Donghui Lu; Peixian Wu; Yali Dai; Xiaojuan Sun; Zesong Li; Aifa Tang; Shilong Zhong; Xiaoping Li; Weineng Chen; Ran Xu; Mingbang Wang; Qiang Feng; Meihua Gong; Jing Yu; Yanyan Zhang; Ming Zhang; Torben Hansen; Gaston Sanchez; Jeroen Raes; Gwen Falony; Shujiro Okuda; Mathieu Almeida; Emmanuelle LeChatelier; Pierre Renault; Nicolas Pons; Jean-Michel Batto; Zhaoxi Zhang; Hua Chen; Ruifu Yang; Weimou Zheng; Songgang Li; Huanming Yang; Jian Wang; S Dusko Ehrlich; Rasmus Nielsen; Oluf Pedersen; Karsten Kristiansen; Jun Wang
Journal:  Nature       Date:  2012-09-26       Impact factor: 49.962

3.  Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells.

Authors:  Jennifer E Bruin; Suheda Erener; Javier Vela; Xiaoke Hu; James D Johnson; Harley T Kurata; Francis C Lynn; James M Piret; Ali Asadi; Alireza Rezania; Timothy J Kieffer
Journal:  Stem Cell Res       Date:  2013-10-16       Impact factor: 2.020

4.  Variation in the safety of induced pluripotent stem cell lines.

Authors:  Kyoko Miura; Yohei Okada; Takashi Aoi; Aki Okada; Kazutoshi Takahashi; Keisuke Okita; Masato Nakagawa; Michiyo Koyanagi; Koji Tanabe; Mari Ohnuki; Daisuke Ogawa; Eiji Ikeda; Hideyuki Okano; Shinya Yamanaka
Journal:  Nat Biotechnol       Date:  2009-07-09       Impact factor: 54.908

5.  Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults.

Authors:  Nadja Larsen; Finn K Vogensen; Frans W J van den Berg; Dennis Sandris Nielsen; Anne Sofie Andreasen; Bente K Pedersen; Waleed Abu Al-Soud; Søren J Sørensen; Lars H Hansen; Mogens Jakobsen
Journal:  PLoS One       Date:  2010-02-05       Impact factor: 3.240

6.  Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.

Authors:  Jaspal S Kooner; Danish Saleheen; Xueling Sim; Joban Sehmi; Weihua Zhang; Philippe Frossard; Latonya F Been; Kee-Seng Chia; Antigone S Dimas; Neelam Hassanali; Tazeen Jafar; Jeremy B M Jowett; Xinzhong Li; Venkatesan Radha; Simon D Rees; Fumihiko Takeuchi; Robin Young; Tin Aung; Abdul Basit; Manickam Chidambaram; Debashish Das; Elin Grundberg; Asa K Hedman; Zafar I Hydrie; Muhammed Islam; Chiea-Chuen Khor; Sudhir Kowlessur; Malene M Kristensen; Samuel Liju; Wei-Yen Lim; David R Matthews; Jianjun Liu; Andrew P Morris; Alexandra C Nica; Janani M Pinidiyapathirage; Inga Prokopenko; Asif Rasheed; Maria Samuel; Nabi Shah; A Samad Shera; Kerrin S Small; Chen Suo; Ananda R Wickremasinghe; Tien Yin Wong; Mingyu Yang; Fan Zhang; Goncalo R Abecasis; Anthony H Barnett; Mark Caulfield; Panos Deloukas; Timothy M Frayling; Philippe Froguel; Norihiro Kato; Prasad Katulanda; M Ann Kelly; Junbin Liang; Viswanathan Mohan; Dharambir K Sanghera; James Scott; Mark Seielstad; Paul Z Zimmet; Paul Elliott; Yik Ying Teo; Mark I McCarthy; John Danesh; E Shyong Tai; John C Chambers
Journal:  Nat Genet       Date:  2011-08-28       Impact factor: 38.330

7.  Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells.

Authors:  Richard Siller; Sebastian Greenhough; Elena Naumovska; Gareth J Sullivan
Journal:  Stem Cell Reports       Date:  2015-04-30       Impact factor: 7.765

Review 8.  Early Treatment with Basal Insulin Glargine in People with Type 2 Diabetes: Lessons from ORIGIN and Other Cardiovascular Trials.

Authors:  Markolf Hanefeld; Louis Monnier; Oliver Schnell; David Owens
Journal:  Diabetes Ther       Date:  2016-02-10       Impact factor: 2.945

Review 9.  Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools.

Authors:  Adrian Kee Keong Teo; Manoj K Gupta; Alessandro Doria; Rohit N Kulkarni
Journal:  Mol Metab       Date:  2015-06-20       Impact factor: 7.422

10.  Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice.

Authors:  Jennifer E Bruin; Ali Asadi; Jessica K Fox; Suheda Erener; Alireza Rezania; Timothy J Kieffer
Journal:  Stem Cell Reports       Date:  2015-11-19       Impact factor: 7.765
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  4 in total

1.  Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary.

Authors:  Elizabeth T Ables; Daniela Drummond-Barbosa
Journal:  Curr Stem Cell Rep       Date:  2017-02-01

Review 2.  Stem Cell-Derived Islets for Type 2 Diabetes.

Authors:  Andrew Salib; Fritz Cayabyab; Eiji Yoshihara
Journal:  Int J Mol Sci       Date:  2022-05-04       Impact factor: 6.208

3.  Abnormal exocrine-endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8.

Authors:  Helge Raeder; Anders Molven; Sevim Kahraman; Ercument Dirice; Giorgio Basile; Danielle Diegisser; Jahedul Alam; Bente B Johansson; Manoj K Gupta; Jiang Hu; Ling Huang; Chew-Li Soh; Danwei Huangfu; Senthil K Muthuswamy; Rohit N Kulkarni
Journal:  Nat Metab       Date:  2022-01-20

4.  Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells.

Authors:  Sevim Kahraman; Debasish Manna; Ercument Dirice; Basudeb Maji; Jonnell Small; Bridget K Wagner; Amit Choudhary; Rohit N Kulkarni
Journal:  Life Sci Alliance       Date:  2021-01-29
  4 in total

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