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Literature DB >> 19590502

Variation in the safety of induced pluripotent stem cell lines.

Kyoko Miura¹, Yohei Okada, Takashi Aoi, Aki Okada, Kazutoshi Takahashi, Keisuke Okita, Masato Nakagawa, Michiyo Koyanagi, Koji Tanabe, Mari Ohnuki, Daisuke Ogawa, Eiji Ikeda, Hideyuki Okano, Shinya Yamanaka.

Abstract

We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. Teratoma-formation of SNS from embryonic fibroblast-derived iPS cells was similar to that of SNS from embryonic stem (ES) cells. In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells.

Entities: Disease Species

Mesh：

Year: 2009 PMID： 19590502 DOI： 10.1038/nbt.1554

Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908

23 in total

1. Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells.

Authors: Yohei Okada; Arifumi Matsumoto; Takuya Shimazaki; Ryosuke Enoki; Amane Koizumi; Seiji Ishii; Yasuto Itoyama; Gen Sobue; Hideyuki Okano
Journal: Stem Cells Date: 2008-08-28 Impact factor: 6.277

2. c-Myc is dispensable for direct reprogramming of mouse fibroblasts.

Authors: Marius Wernig; Alexander Meissner; John P Cassady; Rudolf Jaenisch
Journal: Cell Stem Cell Date: 2007-12-13 Impact factor: 24.633

3. Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals.

Authors: V L Meiner; S Cases; H M Myers; E R Sande; S Bellosta; M Schambelan; R E Pitas; J McGuire; J Herz; R V Farese
Journal: Proc Natl Acad Sci U S A Date: 1996-11-26 Impact factor: 11.205

Variation in the safety of induced pluripotent stem cell lines.

1. Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells.

2. c-Myc is dispensable for direct reprogramming of mouse fibroblasts.

3. Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals.

4. Generation of induced pluripotent stem cells from human blood.

5. Reprogramming of human somatic cells to pluripotency with defined factors.

6. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors.

7. Generation of germline-competent induced pluripotent stem cells.

8. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.

9. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.

10. Reprogramming of pancreatic beta cells into induced pluripotent stem cells.

1. Impaired neural differentiation potency by retinoic acid receptor-α pathway defect in induced pluripotent stem cells.

2. Understanding the first steps in embryonic stem cell exit from the pluripotent state.

3. Induced pluripotent stem cells for neural tissue engineering.

4. The labyrinth of nuclear reprogramming.

Review 5. Stem cell therapy for cerebral ischemia: from basic science to clinical applications.

6. Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.

7. Craniofacial reconstruction with induced pluripotent stem cells.

8. Variation in hematopoietic potential of induced pluripotent stem cell lines.

9. Protein transduction from retroviral Gag precursors.

10. Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors.