Literature DB >> 27308627

Toppling high-grade pulmonary neuroendocrine tumors with a DLL3-targeted trojan horse.

Scott J Dylla1.   

Abstract

Delta-like protein 3 (DLL3) is a novel and tractable tumor-initiating cell-associated target for the antibody-drug conjugate SC16LD6.5 in high-grade pulmonary neuroendocrine tumors. Elevated expression of DLL3, an inhibitor of Notch pathway activation, marks the second recent observation that impairment of Notch receptor signaling may play a critical role in neuroendocrine tumorigenesis.

Entities:  

Keywords:  DLL3; Notch; SCLC; TIC; Tumor-initiating cell

Year:  2016        PMID： 27308627      PMCID： PMC4905406          DOI： 10.1080/23723556.2015.1101515

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.

Authors:  Laura R Saunders; Alexander J Bankovich; Wade C Anderson; Monette A Aujay; Sheila Bheddah; KristenAnn Black; Radhika Desai; Paul A Escarpe; Johannes Hampl; Amy Laysang; David Liu; Javier Lopez-Molina; Milly Milton; Albert Park; Marybeth A Pysz; Hui Shao; Brian Slingerland; Michael Torgov; Samuel A Williams; Orit Foord; Philip Howard; Jacek Jassem; Andrzej Badzio; Piotr Czapiewski; David H Harpole; Afshin Dowlati; Pierre P Massion; William D Travis; M Catherine Pietanza; J T Poirier; Charles M Rudin; Robert A Stull; Scott J Dylla
Journal:  Sci Transl Med       Date:  2015-08-26       Impact factor: 17.956

Review 2.  Neuroendocrine tumors of the lung: an update.

Authors:  Natasha Rekhtman
Journal:  Arch Pathol Lab Med       Date:  2010-11       Impact factor: 5.534

3.  Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis.

Authors:  Gavin Chapman; Duncan B Sparrow; Elisabeth Kremmer; Sally L Dunwoodie
Journal:  Hum Mol Genet       Date:  2010-12-07       Impact factor: 6.150

Review 4.  Novel strategies for the treatment of small-cell lung carcinoma.

Authors:  William N William; Bonnie S Glisson
Journal:  Nat Rev Clin Oncol       Date:  2011-06-21       Impact factor: 66.675

5.  Comprehensive genomic profiles of small cell lung cancer.

Authors:  Julie George; Jing Shan Lim; Se Jin Jang; Yupeng Cun; Luka Ozretić; Gu Kong; Frauke Leenders; Xin Lu; Lynnette Fernández-Cuesta; Graziella Bosco; Christian Müller; Ilona Dahmen; Nadine S Jahchan; Kwon-Sik Park; Dian Yang; Anthony N Karnezis; Dedeepya Vaka; Angela Torres; Maia Segura Wang; Jan O Korbel; Roopika Menon; Sung-Min Chun; Deokhoon Kim; Matt Wilkerson; Neil Hayes; David Engelmann; Brigitte Pützer; Marc Bos; Sebastian Michels; Ignacija Vlasic; Danila Seidel; Berit Pinther; Philipp Schaub; Christian Becker; Janine Altmüller; Jun Yokota; Takashi Kohno; Reika Iwakawa; Koji Tsuta; Masayuki Noguchi; Thomas Muley; Hans Hoffmann; Philipp A Schnabel; Iver Petersen; Yuan Chen; Alex Soltermann; Verena Tischler; Chang-min Choi; Yong-Hee Kim; Pierre P Massion; Yong Zou; Dragana Jovanovic; Milica Kontic; Gavin M Wright; Prudence A Russell; Benjamin Solomon; Ina Koch; Michael Lindner; Lucia A Muscarella; Annamaria la Torre; John K Field; Marko Jakopovic; Jelena Knezevic; Esmeralda Castaños-Vélez; Luca Roz; Ugo Pastorino; Odd-Terje Brustugun; Marius Lund-Iversen; Erik Thunnissen; Jens Köhler; Martin Schuler; Johan Botling; Martin Sandelin; Montserrat Sanchez-Cespedes; Helga B Salvesen; Viktor Achter; Ulrich Lang; Magdalena Bogus; Peter M Schneider; Thomas Zander; Sascha Ansén; Michael Hallek; Jürgen Wolf; Martin Vingron; Yasushi Yatabe; William D Travis; Peter Nürnberg; Christian Reinhardt; Sven Perner; Lukas Heukamp; Reinhard Büttner; Stefan A Haas; Elisabeth Brambilla; Martin Peifer; Julien Sage; Roman K Thomas
Journal:  Nature       Date:  2015-07-13       Impact factor: 49.962

6.  An achaete-scute homologue essential for neuroendocrine differentiation in the lung.

Authors:  M Borges; R I Linnoila; H J van de Velde; H Chen; B D Nelkin; M Mabry; S B Baylin; D W Ball
Journal:  Nature       Date:  1997-04-24       Impact factor: 49.962

7.  Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer.

Authors:  Tianyun Jiang; Brendan J Collins; Ning Jin; David N Watkins; Malcolm V Brock; William Matsui; Barry D Nelkin; Douglas W Ball
Journal:  Cancer Res       Date:  2009-01-27       Impact factor: 12.701

8.  RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.

Authors:  Matthew J Niederst; Lecia V Sequist; John T Poirier; Craig H Mermel; Elizabeth L Lockerman; Angel R Garcia; Ryohei Katayama; Carlotta Costa; Kenneth N Ross; Teresa Moran; Emily Howe; Linnea E Fulton; Hillary E Mulvey; Lindsay A Bernardo; Farhiya Mohamoud; Norikatsu Miyoshi; Paul A VanderLaan; Daniel B Costa; Pasi A Jänne; Darrell R Borger; Sridhar Ramaswamy; Toshi Shioda; Anthony J Iafrate; Gad Getz; Charles M Rudin; Mari Mino-Kenudson; Jeffrey A Engelman
Journal:  Nat Commun       Date:  2015-03-11       Impact factor: 14.919

9.  O-fucosylation of DLL3 is required for its function during somitogenesis.

Authors:  Katrin Serth; Karin Schuster-Gossler; Elisabeth Kremmer; Birte Hansen; Britta Marohn-Köhn; Achim Gossler
Journal:  PLoS One       Date:  2015-04-09       Impact factor: 3.240

10.  Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells.

Authors:  Mitsuru Morimoto; Ryuichi Nishinakamura; Yumiko Saga; Raphael Kopan
Journal:  Development       Date:  2012-12-01       Impact factor: 6.868
  10 in total
  9 in total

1.  Noninvasive Interrogation of DLL3 Expression in Metastatic Small Cell Lung Cancer.

Authors:  Sai Kiran Sharma; Jacob Pourat; Dalya Abdel-Atti; Sean D Carlin; Alessandra Piersigilli; Alexander J Bankovich; Eric E Gardner; Omar Hamdy; Kumiko Isse; Sheila Bheddah; Joseph Sandoval; Kristen M Cunanan; Eric B Johansen; Viola Allaj; Vikram Sisodiya; David Liu; Brian M Zeglis; Charles M Rudin; Scott J Dylla; John T Poirier; Jason S Lewis
Journal:  Cancer Res       Date:  2017-05-09       Impact factor: 12.701

2.  Transcriptomic and Protein Analysis of Small-cell Bladder Cancer (SCBC) Identifies Prognostic Biomarkers and DLL3 as a Relevant Therapeutic Target.

Authors:  Vadim S Koshkin; Jorge A Garcia; Jordan Reynolds; Paul Elson; Cristina Magi-Galluzzi; Jesse K McKenney; Kumiko Isse; Evan Bishop; Laura R Saunders; Aysegul Balyimez; Summya Rashid; Ming Hu; Andrew J Stephenson; Amr F Fergany; Byron H Lee; Georges-Pascal Haber; Afshin Dowlati; Timothy Gilligan; Moshe C Ornstein; Brian I Rini; Mohamed E Abazeed; Omar Y Mian; Petros Grivas
Journal:  Clin Cancer Res       Date:  2018-10-16       Impact factor: 12.531

3.  SC-002 in patients with relapsed or refractory small cell lung cancer and large cell neuroendocrine carcinoma: Phase 1 study.

Authors:  Daniel Morgensztern; Melissa Johnson; Charles M Rudin; Michael Rossi; Mirella Lazarov; Daniel Brickman; Abraham Fong
Journal:  Lung Cancer       Date:  2020-05-12       Impact factor: 5.705

Review 4.  Small-cell lung cancer: what we know, what we need to know and the path forward.

Authors:  Adi F Gazdar; Paul A Bunn; John D Minna
Journal:  Nat Rev Cancer       Date:  2017-10-27       Impact factor: 60.716

Review 5.  Molecular Pathology of Pulmonary Large Cell Neuroendocrine Carcinoma: Novel Concepts and Treatments.

Authors:  Masayo Yoshimura; Kurumi Seki; Andrey Bychkov; Junya Fukuoka
Journal:  Front Oncol       Date:  2021-04-22       Impact factor: 6.244

6.  ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation.

Authors:  Sk Kayum Alam; Li Wang; Yanan Ren; Christina E Hernandez; Farhad Kosari; Anja C Roden; Rendong Yang; Luke H Hoeppner
Journal:  Br J Cancer       Date:  2020-06-05       Impact factor: 7.640

7.  Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer.

Authors:  Paloma Cejas; Yingtian Xie; Alba Font-Tello; Klothilda Lim; Sudeepa Syamala; Xintao Qiu; Alok K Tewari; Neel Shah; Holly M Nguyen; Radhika A Patel; Lisha Brown; Ilsa Coleman; Wenzel M Hackeng; Lodewijk Brosens; Koen M A Dreijerink; Leigh Ellis; Sarah Abou Alaiwi; Ji-Heui Seo; Sylvan Baca; Himisha Beltran; Francesca Khani; Mark Pomerantz; Alessandra Dall'Agnese; Jett Crowdis; Eliezer M Van Allen; Joaquim Bellmunt; Colm Morrisey; Peter S Nelson; James DeCaprio; Anna Farago; Nicholas Dyson; Benjamin Drapkin; X Shirley Liu; Matthew Freedman; Michael C Haffner; Eva Corey; Myles Brown; Henry W Long
Journal:  Nat Commun       Date:  2021-10-01       Impact factor: 17.694

8.  Elevated DLL3 in stomach cancer by tumor-associated macrophages enhances cancer-cell proliferation and cytokine secretion of macrophages.

Authors:  Jian-Bin Ye; Jun-Jie Wen; Dan-Lin Wu; Bing-Xin Hu; Mei-Qun Luo; Yan-Qing Lin; Yun-Shan Ning; Yan Li
Journal:  Gastroenterol Rep (Oxf)       Date:  2021-11-25

9.  Tumor Mutational Burden and Genomic Alterations in Chinese Small Cell Lung Cancer Measured by Whole-Exome Sequencing.

Authors:  Shan Su; Jian-Jun Zou; Yun-Yun Zeng; Wen-Chang Cen; Wei Zhou; Yan Liu; Duo-Hua Su; Xian-Lan Zhang; Hui-Yi Huang; An Lei; Zhi-Hao Huang; Yun Jin; Lei Li; Ning Su; Ya-Lin Xie; Zhen-Gang Zhao; Jian-Xiong Liu
Journal:  Biomed Res Int       Date:  2019-11-06       Impact factor: 3.411
  9 in total

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