Literature DB >> 27308619

RNA editing in cancer: Mechanistic, prognostic, and therapeutic implications.

Leng Han1, Han Liang2.   

Abstract

We have recently provided a comprehensive analysis of A-to-I RNA editing events in various cancer types, revealing many clinically relevant RNA editing sites and demonstrating that RNA editing can selectively affect cancer drug sensitivity. Our results unveil mechanistic, prognostic, and therapeutic implications for RNA editing in cancer.

Entities:  

Keywords:  Driver events; RNA editing; drug sensitivity; pancancer analysis; prognostic marker

Year:  2015        PMID： 27308619      PMCID： PMC4905409          DOI： 10.1080/23723556.2015.1117702

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

Review 1.  The many roles of an RNA editor.

Authors:  L P Keegan; A Gallo; M A O'Connell
Journal:  Nat Rev Genet       Date:  2001-11       Impact factor: 53.242

Review 2.  RNA editing by adenosine deaminases that act on RNA.

Authors:  Brenda L Bass
Journal:  Annu Rev Biochem       Date:  2001-11-09       Impact factor: 23.643

3.  Lack of evidence for existence of noncanonical RNA editing.

Authors:  Robert Piskol; Zhiyu Peng; Jun Wang; Jin Billy Li
Journal:  Nat Biotechnol       Date:  2013-01       Impact factor: 54.908

4.  The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.

Authors:  Leng Han; Lixia Diao; Shuangxing Yu; Xiaoyan Xu; Jie Li; Rui Zhang; Yang Yang; Henrica M J Werner; A Karina Eterovic; Yuan Yuan; Jun Li; Nikitha Nair; Rosalba Minelli; Yiu Huen Tsang; Lydia W T Cheung; Kang Jin Jeong; Jason Roszik; Zhenlin Ju; Scott E Woodman; Yiling Lu; Kenneth L Scott; Jin Billy Li; Gordon B Mills; Han Liang
Journal:  Cancer Cell       Date:  2015-10-01       Impact factor: 31.743

5.  Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.

Authors:  Leilei Chen; Yan Li; Chi Ho Lin; Tim Hon Man Chan; Raymond Kwok Kei Chow; Yangyang Song; Ming Liu; Yun-Fei Yuan; Li Fu; Kar Lok Kong; Lihua Qi; Yan Li; Na Zhang; Amy Hin Yan Tong; Dora Lai-Wan Kwong; Kwan Man; Chung Mau Lo; Si Lok; Daniel G Tenen; Xin-Yuan Guan
Journal:  Nat Med       Date:  2013-01-06       Impact factor: 53.440

6.  TANRIC: An Interactive Open Platform to Explore the Function of lncRNAs in Cancer.

Authors:  Jun Li; Leng Han; Paul Roebuck; Lixia Diao; Lingxiang Liu; Yuan Yuan; John N Weinstein; Han Liang
Journal:  Cancer Res       Date:  2015-07-24       Impact factor: 12.701

7.  RADAR: a rigorously annotated database of A-to-I RNA editing.

Authors:  Gokul Ramaswami; Jin Billy Li
Journal:  Nucleic Acids Res       Date:  2013-10-25       Impact factor: 16.971

8.  The Pan-Cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes.

Authors:  Leng Han; Yuan Yuan; Siyuan Zheng; Yang Yang; Jun Li; Mary E Edgerton; Lixia Diao; Yanxun Xu; Roeland G W Verhaak; Han Liang
Journal:  Nat Commun       Date:  2014-07-07       Impact factor: 14.919
  8 in total
  4 in total

1.  Multifaceted role of RNA editing in promoting loss-of-function of PODXL in cancer.

Authors:  Ting Fu; Tracey W Chan; Jae Hoon Bahn; Tae-Hyung Kim; Amy C Rowat; Xinshu Xiao
Journal:  iScience       Date:  2022-08-02

2.  ADAR2 Protein Is Associated with Overall Survival in GBM Patients and Its Decrease Triggers the Anchorage-Independent Cell Growth Signature.

Authors:  Valeriana Cesarini; Domenico Alessandro Silvestris; Federica Galeano; Valentina Tassinari; Maurizio Martini; Franco Locatelli; Angela Gallo
Journal:  Biomolecules       Date:  2022-08-19

3.  LNCediting: a database for functional effects of RNA editing in lncRNAs.

Authors:  Jing Gong; Chunjie Liu; Wei Liu; Yu Xiang; Lixia Diao; An-Yuan Guo; Leng Han
Journal:  Nucleic Acids Res       Date:  2016-09-19       Impact factor: 16.971

4.  RNA editing alterations define manifestation of prion diseases.

Authors:  Eirini Kanata; Franc Llorens; Dimitra Dafou; Athanasios Dimitriadis; Katrin Thüne; Konstantinos Xanthopoulos; Nikolaos Bekas; Juan Carlos Espinosa; Matthias Schmitz; Alba Marín-Moreno; Vincenzo Capece; Orr Shormoni; Olivier Andréoletti; Stefan Bonn; Juan María Torres; Isidre Ferrer; Inga Zerr; Theodoros Sklaviadis
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-06       Impact factor: 11.205
  4 in total

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