Literature DB >> 27308618

Chewing the fat for Akt1 inhibition and oncosuppression.

Sara M Nowinski1, Ashley Solmonson2, Edward M Mills2.   

Abstract

The catabolic and energy-dissipating actions of mitochondrial uncoupling proteins (UCPs) conflict with many of the bioenergetic hallmarks of malignancy. We have recently demonstrated that overexpression of mitochondrial uncoupling protein 3 (Ucp3) in the basal epidermis impedes skin tumorigenesis through a novel pathway of thymoma viral proto-oncogene 1 (Akt1) inhibition via increased mitochondrial lipid catabolism.

Entities:  

Keywords:  Akt; UCP3; keratinocytes; lipid catabolism; metabolomics; mitochondria; skin cancer; uncoupling; uncoupling proteins

Year:  2015        PMID： 27308618      PMCID： PMC4905408          DOI： 10.1080/23723556.2015.1102795

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Novel bioactive glycerol-based lysophospholipids: new data -- new insight into their function.

Authors:  Anna Grzelczyk; Edyta Gendaszewska-Darmach
Journal:  Biochimie       Date:  2012-10-23       Impact factor: 4.079

2.  Arachidonic acid promotes migration and invasion through a PI3K/Akt-dependent pathway in MDA-MB-231 breast cancer cells.

Authors:  Socrates Villegas-Comonfort; Rocio Castillo-Sanchez; Nathalia Serna-Marquez; Pedro Cortes-Reynosa; Eduardo Perez Salazar
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  2014-02-12       Impact factor: 4.006

Review 3.  The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3.

Authors:  Telma C Esteves; Martin D Brand
Journal:  Biochim Biophys Acta       Date:  2005-08-15

4.  v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid.

Authors:  A Leder; A Kuo; R D Cardiff; E Sinn; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

5.  Lysophospholipids prevent binding of a cytolytic protein ostreolysin to cholesterol-enriched membrane domains.

Authors:  Helena H Chowdhury; Katja Rebolj; Marko Kreft; Robert Zorec; Peter Macek; Kristina Sepcić
Journal:  Toxicon       Date:  2008-03-18       Impact factor: 3.033

6.  Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype.

Authors:  Melanie Schüppel; Ulrich Kürschner; Ulrike Kleuser; Monika Schäfer-Korting; Burkhard Kleuser
Journal:  J Invest Dermatol       Date:  2008-01-24       Impact factor: 8.551

Review 7.  The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.

Authors:  Ralph J DeBerardinis; Julian J Lum; Georgia Hatzivassiliou; Craig B Thompson
Journal:  Cell Metab       Date:  2008-01       Impact factor: 27.287

8.  Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells.

Authors:  Zhennan Gu; Jiansheng Wu; Shihua Wang; Janel Suburu; Haiqin Chen; Michael J Thomas; Lihong Shi; Iris J Edwards; Isabelle M Berquin; Yong Q Chen
Journal:  Carcinogenesis       Date:  2013-04-30       Impact factor: 4.944

9.  Mitochondrial respiratory uncoupling promotes keratinocyte differentiation and blocks skin carcinogenesis.

Authors:  C U Lago; S M Nowinski; J E Rundhaug; M E Pfeiffer; K Kiguchi; K Hirasaka; X Yang; E M Abramson; S B Bratton; O Rho; R Colavitti; M A Kenaston; T Nikawa; C Trempus; J Digiovanni; S M Fischer; E M Mills
Journal:  Oncogene       Date:  2012-01-23       Impact factor: 8.756

10.  Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis.

Authors:  Sara M Nowinski; Ashley Solmonson; Joyce E Rundhaug; Okkyung Rho; Jiyoon Cho; Cory U Lago; Christopher L Riley; Sunhee Lee; Shohei Kohno; Christine K Dao; Takeshi Nikawa; Shawn B Bratton; Casey W Wright; Susan M Fischer; John DiGiovanni; Edward M Mills
Journal:  Nat Commun       Date:  2015-08-27       Impact factor: 14.919
  10 in total

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