Literature DB >> 27308607

Death by a thousand knives: Multiple BH3-only proteins are required for maximal apoptosis triggered through the BCR.

Matthew J Carter1, Mark S Cragg1.   

Abstract

The B-cell receptor (BCR) represents a key driver of B-cell development. Consequently, multiple mechanisms link inappropriate BCR signaling to apoptosis. Recently, we characterized the molecular regulators involved in lymphoma cells, confirming a major role for Bcl-2 interacting mediator of cell death (Bim) and supplementary roles for Bcl-2 interacting killer (Bik) and Noxa, and showing that all 3 proteins are required for maximal apoptosis.

Entities:  

Keywords:  Apoptosis; B-cell receptor (BCR); BCL2; BH3-only; Bik; Bim; Noxa; mitochondrial outer membrane permeabilization (MOMP)

Year:  2015        PMID： 27308607      PMCID： PMC4905387          DOI： 10.1080/23723556.2015.1084444

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

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Authors:  R R Hardy; K Hayakawa
Journal:  Annu Rev Immunol       Date:  2001       Impact factor: 28.527

2.  Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation.

Authors:  Deepak Nijhawan; Min Fang; Elie Traer; Qing Zhong; Wenhua Gao; Fenghe Du; Xiaodong Wang
Journal:  Genes Dev       Date:  2003-06-03       Impact factor: 11.361

3.  In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

Authors:  K P Lam; R Kühn; K Rajewsky
Journal:  Cell       Date:  1997-09-19       Impact factor: 41.582

Review 4.  Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

Authors:  Peter E Czabotar; Guillaume Lessene; Andreas Strasser; Jerry M Adams
Journal:  Nat Rev Mol Cell Biol       Date:  2014-01       Impact factor: 94.444

5.  Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.

Authors:  R Eric Davis; Vu N Ngo; Georg Lenz; Pavel Tolar; Ryan M Young; Paul B Romesser; Holger Kohlhammer; Laurence Lamy; Hong Zhao; Yandan Yang; Weihong Xu; Arthur L Shaffer; George Wright; Wenming Xiao; John Powell; Jian-Kang Jiang; Craig J Thomas; Andreas Rosenwald; German Ott; Hans Konrad Muller-Hermelink; Randy D Gascoyne; Joseph M Connors; Nathalie A Johnson; Lisa M Rimsza; Elias Campo; Elaine S Jaffe; Wyndham H Wilson; Jan Delabie; Erlend B Smeland; Richard I Fisher; Rita M Braziel; Raymond R Tubbs; J R Cook; Dennis D Weisenburger; Wing C Chan; Susan K Pierce; Louis M Staudt
Journal:  Nature       Date:  2010-01-07       Impact factor: 49.962

6.  The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice.

Authors:  J M Adams; A W Harris; C A Pinkert; L M Corcoran; W S Alexander; S Cory; R D Palmiter; R L Brinster
Journal:  Nature       Date:  1985 Dec 12-18       Impact factor: 49.962

7.  Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death.

Authors:  Leigh Coultas; Philippe Bouillet; Edouard G Stanley; Thomas C Brodnicki; Jerry M Adams; Andreas Strasser
Journal:  Mol Cell Biol       Date:  2004-02       Impact factor: 4.272

8.  Apoptosis via the B cell antigen receptor requires Bax translocation and involves mitochondrial depolarization, cytochrome C release, and caspase-9 activation.

Authors:  Eric Eldering; Wendelina J M Mackus; Ingrid A M Derks; Ludo M Evers; Esther Beuling; Peter Teeling; Susanne M A Lens; Marinus H J van Oers; René A W van Lier
Journal:  Eur J Immunol       Date:  2004-07       Impact factor: 5.532

9.  Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia.

Authors:  John C Byrd; Richard R Furman; Steven E Coutre; Ian W Flinn; Jan A Burger; Kristie A Blum; Barbara Grant; Jeff P Sharman; Morton Coleman; William G Wierda; Jeffrey A Jones; Weiqiang Zhao; Nyla A Heerema; Amy J Johnson; Juthamas Sukbuntherng; Betty Y Chang; Fong Clow; Eric Hedrick; Joseph J Buggy; Danelle F James; Susan O'Brien
Journal:  N Engl J Med       Date:  2013-06-19       Impact factor: 91.245

10.  Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells.

Authors:  Anselm Enders; Philippe Bouillet; Hamsa Puthalakath; Yuekang Xu; David M Tarlinton; Andreas Strasser
Journal:  J Exp Med       Date:  2003-09-29       Impact factor: 14.307
  10 in total

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