Literature DB >> 3906410

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice.

J M Adams, A W Harris, C A Pinkert, L M Corcoran, W S Alexander, S Cory, R D Palmiter, R L Brinster.   

Abstract

Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice should aid study of lymphoma development, B-cell ontogeny and immunoglobulin regulation.

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Year:  1985        PMID： 3906410     DOI： 10.1038/318533a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  618 in total

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3.  An Integrated Genetic-Genomic Approach for the Identification of Novel Cancer Loci in Mice Sensitized to c-Myc-Induced Apoptosis.

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Journal:  Genes Cancer       Date:  2010-05

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Journal:  Leukemia       Date:  2014-11-14       Impact factor: 11.528

5.  Chromosomal location targets different MYC family gene members for oncogenic translocations.

Authors:  Monica Gostissa; Sheila Ranganath; Julia M Bianco; Frederick W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-27       Impact factor: 11.205

6.  Integration of the BALB/c ecotropic provirus into the colony-stimulating factor-1 growth factor locus in a myc retrovirus-induced murine monocyte tumor.

Authors:  W R Baumbach; E M Colston; M D Cole
Journal:  J Virol       Date:  1988-09       Impact factor: 5.103

7.  Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model.

Authors:  E V Schmidt; P K Pattengale; L Weir; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

8.  Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.

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Journal:  Cancer Res       Date:  2013-11-27       Impact factor: 12.701

9.  AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.

Authors:  Davide F Robbiani; Anne Bothmer; Elsa Callen; Bernardo Reina-San-Martin; Yair Dorsett; Simone Difilippantonio; Daniel J Bolland; Hua Tang Chen; Anne E Corcoran; André Nussenzweig; Michel C Nussenzweig
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Review 10.  Mutations in the noncoding genome.

Authors:  Cheryl A Scacheri; Peter C Scacheri
Journal:  Curr Opin Pediatr       Date:  2015-12       Impact factor: 2.856
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