Literature DB >> 27308598

Pontin, a novel interactor of mutant p53 that promotes mutant p53 gain of function.

Yuhan Zhao1, Xuetian Yue1, Wenwei Hu1.   

Abstract

Many tumor-associated mutant p53 proteins gain new activities to promote tumorigenesis, which is termed as gain of function of mutant p53 (GOF). Currently, the mechanisms of mutant p53 GOF remain elusive. We recently identified the AAA+ ATPase pontin as a critical regulator of mutant p53 GOF, thus providing a novel mechanism for mutant p53 GOF.

Entities:  

Keywords:  Gain of function; mutant p53;pontin; tumorigenesis

Year:  2015        PMID： 27308598      PMCID： PMC4905376          DOI： 10.1080/23723556.2015.1076587

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Chaperone-like activity of the AAA+ proteins Rvb1 and Rvb2 in the assembly of various complexes.

Authors:  Nardin Nano; Walid A Houry
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2013-03-25       Impact factor: 6.237

2.  A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis.

Authors:  Kenzui Taniue; Takeaki Oda; Tomoatsu Hayashi; Masumi Okuno; Tetsu Akiyama
Journal:  EMBO Rep       Date:  2011-07-01       Impact factor: 8.807

3.  Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53.

Authors:  Y Zhao; C Zhang; X Yue; X Li; J Liu; H Yu; V A Belyi; Q Yang; Z Feng; W Hu
Journal:  Cell Death Differ       Date:  2015-04-10       Impact factor: 15.828

Review 4.  Mutant p53: one name, many proteins.

Authors:  William A Freed-Pastor; Carol Prives
Journal:  Genes Dev       Date:  2012-06-15       Impact factor: 11.361

5.  Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells.

Authors:  Dun Li; Natalia D Marchenko; Ramona Schulz; Victoria Fischer; Talia Velasco-Hernandez; Flaminia Talos; Ute M Moll
Journal:  Mol Cancer Res       Date:  2011-04-08       Impact factor: 5.852

Review 6.  The P53 pathway: what questions remain to be explored?

Authors:  A J Levine; W Hu; Z Feng
Journal:  Cell Death Differ       Date:  2006-06       Impact factor: 15.828

Review 7.  p53 mutations in cancer.

Authors:  Patricia A J Muller; Karen H Vousden
Journal:  Nat Cell Biol       Date:  2013-01       Impact factor: 28.824

Review 8.  Pontin and reptin, two related ATPases with multiple roles in cancer.

Authors:  Otmar Huber; Ludovic Ménard; Valérie Haurie; Alexandra Nicou; Danièle Taras; Jean Rosenbaum
Journal:  Cancer Res       Date:  2008-09-01       Impact factor: 12.701

9.  Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis.

Authors:  Tongsen Zheng; Jiabei Wang; Yuhan Zhao; Cen Zhang; Meihua Lin; Xiaowen Wang; Haiyang Yu; Lianxin Liu; Zhaohui Feng; Wenwei Hu
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

10.  Tumour-associated mutant p53 drives the Warburg effect.

Authors:  Cen Zhang; Juan Liu; Yingjian Liang; Rui Wu; Yuhan Zhao; Xuehui Hong; Meihua Lin; Haiyang Yu; Lianxin Liu; Arnold J Levine; Wenwei Hu; Zhaohui Feng
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
  10 in total
  1 in total

1.  Pontin Functions as A Transcriptional Co-activator for Retinoic Acid-induced HOX Gene Expression.

Authors:  Dan Tang; Zhao Zhang; Emily Zboril; Michael D Wetzel; Xinping Xu; Wei Zhang; Lizhen Chen; Zhijie Liu
Journal:  J Mol Biol       Date:  2021-03-11       Impact factor: 6.151
  1 in total

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