Literature DB >> 27308588

Retinoblastoma family proteins: New players in DNA repair by non-homologous end-joining.

Paul H Huang1, Rebecca Cook2, Georgia Zoumpoulidou1, Maciej T Luczynski1, Sibylle Mittnacht2.   

Abstract

Loss of retinoblastoma protein (RB1) function is a major driver in cancer development. We have recently reported that, in addition to its well-documented functions in cell cycle and fate control, RB1 and its paralogs have a novel role in regulating DNA repair by non-homologous end joining (NHEJ). Here we summarize our findings and present mechanistic hypotheses on how RB1 may support the DNA repair process and the therapeutic implications for patients who harbor RB1-negative cancers.

Entities:  

Keywords:  DNA repair; non-homologous end-joining; retinoblastoma protein; tumor suppressor

Year:  2015        PMID： 27308588      PMCID： PMC4905371          DOI： 10.1080/23723556.2015.1053596

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  24 in total

Review 1.  Mechanism and regulation of human non-homologous DNA end-joining.

Authors:  Michael R Lieber; Yunmei Ma; Ulrich Pannicke; Klaus Schwarz
Journal:  Nat Rev Mol Cell Biol       Date:  2003-09       Impact factor: 94.444

Review 2.  RB, the conductor that orchestrates life, death and differentiation.

Authors:  L Khidr; P-L Chen
Journal:  Oncogene       Date:  2006-08-28       Impact factor: 9.867

3.  RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins.

Authors:  A Lai; J M Lee; W M Yang; J A DeCaprio; W G Kaelin; E Seto; P E Branton
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

Review 4.  The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.

Authors:  Michael R Lieber
Journal:  Annu Rev Biochem       Date:  2010       Impact factor: 23.643

5.  The retinoblastoma protein regulates pericentric heterochromatin.

Authors:  Christian E Isaac; Sarah M Francis; Alison L Martens; Lisa M Julian; Laurie A Seifried; Natalie Erdmann; Ulrich K Binné; Lea Harrington; Piotr Sicinski; Nathalie G Bérubé; Nicholas J Dyson; Frederick A Dick
Journal:  Mol Cell Biol       Date:  2006-05       Impact factor: 4.272

6.  Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.

Authors:  Markus Hassler; Shradha Singh; Wyatt W Yue; Maciej Luczynski; Rachid Lakbir; Francisco Sanchez-Sanchez; Thomas Bader; Laurence H Pearl; Sibylle Mittnacht
Journal:  Mol Cell       Date:  2007-11-09       Impact factor: 17.970

7.  Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin.

Authors:  Susana Gonzalo; Marta García-Cao; Mario F Fraga; Gunnar Schotta; Antoine H F M Peters; Shane E Cotter; Raúl Eguía; Douglas C Dean; Manel Esteller; Thomas Jenuwein; María A Blasco
Journal:  Nat Cell Biol       Date:  2005-03-06       Impact factor: 28.824

Review 8.  DNA double-strand break repair pathway choice and cancer.

Authors:  Tomas Aparicio; Richard Baer; Jean Gautier
Journal:  DNA Repair (Amst)       Date:  2014-04-18

9.  A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma.

Authors:  S H Friend; R Bernards; S Rogelj; R A Weinberg; J M Rapaport; D M Albert; T P Dryja
Journal:  Nature       Date:  1986 Oct 16-22       Impact factor: 49.962

10.  Direct involvement of retinoblastoma family proteins in DNA repair by non-homologous end-joining.

Authors:  Rebecca Cook; Georgia Zoumpoulidou; Maciej T Luczynski; Simone Rieger; Jayne Moquet; Victoria J Spanswick; John A Hartley; Kai Rothkamm; Paul H Huang; Sibylle Mittnacht
Journal:  Cell Rep       Date:  2015-03-26       Impact factor: 9.423
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  3 in total

1.  Melanocyte transformation requires complete loss of all pocket protein function via a mechanism that mitigates the need for MAPK pathway activation.

Authors:  I D Tonks; P Mukhopadhyay; W A Schroder; A Sorolla; A W Mould; H Y Handoko; B Ferguson; H K Muller; P Keith; N K Hayward; G J Walker; G F Kay
Journal:  Oncogene       Date:  2017-02-13       Impact factor: 9.867

2.  Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context.

Authors:  Eva Moreno; Shusil K Pandit; Mathilda J M Toussaint; Laura Bongiovanni; Liesbeth Harkema; Saskia C van Essen; Elsbeth A van Liere; Bart Westendorp; Alain de Bruin
Journal:  Cancers (Basel)       Date:  2021-04-23       Impact factor: 6.639

3.  ATM/RB1 mutations predict shorter overall survival in urothelial cancer.

Authors:  Ming Yin; Petros Grivas; Hamid Emamekhoo; Prateek Mendiratta; Siraj Ali; JoAnn Hsu; Monali Vasekar; Joseph J Drabick; Sumanta Pal; Monika Joshi
Journal:  Oncotarget       Date:  2018-03-30
  3 in total

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