Literature DB >> 27308575

Inflammasome-mediated glucocorticoid resistance: The receptor rheostat.

Steven W Paugh1, Erik J Bonten1, William E Evans1.   

Abstract

In primary acute lymphoblastic leukemia cells exhibiting de novo resistance to glucocorticoids, we recently discovered decreased promoter methylation of caspase 1 (CASP1) and NLR family, pyrin domain containing 3 (NLRP3), which resulted in increased transcription, constitutive NALP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome activation, and caspase 1-mediated cleavage of the glucocorticoid receptor. This revealed a novel mechanism of glucocorticoid resistance that was recapitulated in model systems.

Entities:  

Keywords:  CASP1; NALP3; NR3C1; glucocorticoids; inflammasome

Year:  2015        PMID： 27308575      PMCID： PMC4845245          DOI： 10.1080/23723556.2015.1065947

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.

Authors:  C L Wellington; L M Ellerby; A S Hackam; R L Margolis; M A Trifiro; R Singaraja; K McCutcheon; G S Salvesen; S S Propp; M Bromm; K J Rowland; T Zhang; D Rasper; S Roy; N Thornberry; L Pinsky; A Kakizuka; C A Ross; D W Nicholson; D E Bredesen; M R Hayden
Journal:  J Biol Chem       Date:  1998-04-10       Impact factor: 5.157

Review 2.  Function and information content of DNA methylation.

Authors:  Dirk Schübeler
Journal:  Nature       Date:  2015-01-15       Impact factor: 49.962

3.  Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.

Authors:  T Komiyama; C A Ray; D J Pickup; A D Howard; N A Thornberry; E P Peterson; G Salvesen
Journal:  J Biol Chem       Date:  1994-07-29       Impact factor: 5.157

4.  Common risk alleles for inflammatory diseases are targets of recent positive selection.

Authors:  Towfique Raj; Manik Kuchroo; Joseph M Replogle; Soumya Raychaudhuri; Barbara E Stranger; Philip L De Jager
Journal:  Am J Hum Genet       Date:  2013-03-21       Impact factor: 11.025

5.  Patient stratification based on prednisolone-vincristine-asparaginase resistance profiles in children with acute lymphoblastic leukemia.

Authors:  M L Den Boer; D O Harms; R Pieters; K M Kazemier; U Gobel; D Körholz; U Graubner; R J Haas; N Jorch; H J Spaar; G J L Kaspers; W A Kamps; A Van der Does-Van den Berg; E R Van Wering; A J P Veerman; G E Janka-Schaub
Journal:  J Clin Oncol       Date:  2003-09-01       Impact factor: 44.544

Review 6.  The human glucocorticoid receptor: molecular basis of biologic function.

Authors:  Nicolas C Nicolaides; Zoi Galata; Tomoshige Kino; George P Chrousos; Evangelia Charmandari
Journal:  Steroids       Date:  2009-10-07       Impact factor: 2.668

7.  Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution.

Authors:  Matteo Fumagalli; Manuela Sironi; Uberto Pozzoli; Anna Ferrer-Admetlla; Anna Ferrer-Admettla; Linda Pattini; Rasmus Nielsen
Journal:  PLoS Genet       Date:  2011-11-03       Impact factor: 5.917

8.  NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.

Authors:  Steven W Paugh; Erik J Bonten; Daniel Savic; Laura B Ramsey; William E Thierfelder; Prajwal Gurung; R K Subbarao Malireddi; Marcelo Actis; Anand Mayasundari; Jaeki Min; David R Coss; Lucas T Laudermilk; John C Panetta; J Robert McCorkle; Yiping Fan; Kristine R Crews; Gabriele Stocco; Mark R Wilkinson; Antonio M Ferreira; Cheng Cheng; Wenjian Yang; Seth E Karol; Christian A Fernandez; Barthelemy Diouf; Colton Smith; J Kevin Hicks; Alessandra Zanut; Audrey Giordanengo; Daniel Crona; Joy J Bianchi; Linda Holmfeldt; Charles G Mullighan; Monique L den Boer; Rob Pieters; Sima Jeha; Thomas L Dunwell; Farida Latif; Deepa Bhojwani; William L Carroll; Ching-Hon Pui; Richard M Myers; R Kiplin Guy; Thirumala-Devi Kanneganti; Mary V Relling; William E Evans
Journal:  Nat Genet       Date:  2015-05-04       Impact factor: 38.330

9.  Protein painting reveals solvent-excluded drug targets hidden within native protein-protein interfaces.

Authors:  Alessandra Luchini; Virginia Espina; Lance A Liotta
Journal:  Nat Commun       Date:  2014-07-22       Impact factor: 14.919
  9 in total
  5 in total

Review 1.  The Bidirectional Relationship of Depression and Inflammation: Double Trouble.

Authors:  Eléonore Beurel; Marisa Toups; Charles B Nemeroff
Journal:  Neuron       Date:  2020-06-17       Impact factor: 17.173

2.  Intranasal Application of Budesonide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Nucleotide-Binding Oligomerization Domain-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation in Mice.

Authors:  Liang Dong; Yu-Hang Zhu; De-Xing Liu; Juan Li; Peng-Cheng Zhao; Yuan-Ping Zhong; Yong-Qin Chen; Wei Xu; Zhao-Qiong Zhu
Journal:  J Immunol Res       Date:  2019-02-27       Impact factor: 4.818

3.  Prognostic Relevance of Expression of EMP1, CASP1, and NLRP3 Genes in Pediatric B-Lineage Acute Lymphoblastic Leukemia.

Authors:  Jay Singh; Sarita Kumari; Mohit Arora; Deepak Verma; Jayanth Kumar Palanichamy; Rajive Kumar; Gunjan Sharma; Sameer Bakhshi; Deepam Pushpam; M Shadab Ali; Amar Ranjan; Pranay Tanwar; Shyam S Chauhan; Archna Singh; Anita Chopra
Journal:  Front Oncol       Date:  2021-03-05       Impact factor: 5.738

4.  CASPorter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor.

Authors:  Chan Zou; Jordan A Beard; Guoping Yang; William E Evans; Erik J Bonten
Journal:  J Inflamm Res       Date:  2022-02-19

5.  Microneedle-assisted genome editing: A transdermal strategy of targeting NLRP3 by CRISPR-Cas9 for synergistic therapy of inflammatory skin disorders.

Authors:  Tao Wan; Qi Pan; Yuan Ping
Journal:  Sci Adv       Date:  2021-03-10       Impact factor: 14.136
  5 in total

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