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Literature DB >> 27308536

Hepatic cancer stem cells may arise from adult ductal progenitors.

Abstract

Cancer stem cells (CSCs) are defined as cells within tumors that can self-renew and differentiate into heterogeneous lineages of cancerous cells. The origin of CSCs is not well understood. Recent evidence suggests that CSCs in hepatocellular carcinoma could be generated via oncogenic transformation and partial differentiation of adult hepatic ductal progenitor cells.

Entities: Disease

Keywords: PR-SET7; cancer stem cells; ductal progenitors; hepatocellular carcinoma

Year: 2015 PMID： 27308536 PMCID： PMC4845172 DOI： 10.1080/23723556.2015.1021946

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

Review 1. Hepatocellular carcinoma.

Authors: Hashem B El-Serag
Journal: N Engl J Med Date: 2011-09-22 Impact factor: 91.245

2. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling.

Authors: Guobin He; Debanjan Dhar; Hayato Nakagawa; Joan Font-Burgada; Hisanobu Ogata; Yuhong Jiang; Shabnam Shalapour; Ekihiro Seki; Shawn E Yost; Kristen Jepsen; Kelly A Frazer; Olivier Harismendy; Maria Hatziapostolou; Dimitrios Iliopoulos; Atsushi Suetsugu; Robert M Hoffman; Ryosuke Tateishi; Kazuhiko Koike; Michael Karin
Journal: Cell Date: 2013-10-10 Impact factor: 41.582

3. Robust cellular reprogramming occurs spontaneously during liver regeneration.

Authors: Kilangsungla Yanger; Yiwei Zong; Lara R Maggs; Suzanne N Shapira; Ravi Maddipati; Nicole M Aiello; Swan N Thung; Rebecca G Wells; Linda E Greenbaum; Ben Z Stanger
Journal: Genes Dev Date: 2013-03-21 Impact factor: 11.361

Review 4. Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming.

Authors: Atsushi Miyajima; Minoru Tanaka; Tohru Itoh
Journal: Cell Stem Cell Date: 2014-05-01 Impact factor: 24.633

Review 5. Cancer stem cells: current status and evolving complexities.

Authors: Jane E Visvader; Geoffrey J Lindeman
Journal: Cell Stem Cell Date: 2012-06-14 Impact factor: 24.633

Review 6. Molecular pathways: the complex roles of inflammation pathways in the development and treatment of liver cancer.

Authors: Kostas Nikolaou; Michalis Sarris; Iannis Talianidis
Journal: Clin Cancer Res Date: 2013-04-02 Impact factor: 12.531

1 in total

1. Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM).

Authors: Rong Wang; Laixiu Yang; Shen Li; Dongmei Ye; Lihong Yang; Qingyan Liu; Zibo Zhao; Qing Cai; Junzhen Tan; Xiuli Li
Journal: Med Sci Monit Date: 2018-01-21

1 in total

Hepatic cancer stem cells may arise from adult ductal progenitors.

Review 1. Hepatocellular carcinoma.

2. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling.

3. Robust cellular reprogramming occurs spontaneously during liver regeneration.

Review 4. Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming.

Review 5. Cancer stem cells: current status and evolving complexities.

Review 6. Molecular pathways: the complex roles of inflammation pathways in the development and treatment of liver cancer.

7. Adult hepatocytes are generated by self-duplication rather than stem cell differentiation.

8. Cholangiocarcinomas can originate from hepatocytes in mice.

9. Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury.

10. Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers.

1. Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM).