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Literature DB >> 24792114

Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming.

Atsushi Miyajima¹, Minoru Tanaka², Tohru Itoh³.

Abstract

The liver is a central organ for homeostasis with unique regenerative capacities. Mature hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to discern the role of adult liver stem cells in this process. In contrast, stem/progenitor cells in the developing liver have been extensively characterized, and these investigations have informed efforts to produce functional hepatocytes in vitro for cell therapy and drug screening. In this Review, we describe recent advances in the characterization of liver stem cells and discuss evidence supporting and refuting whether self-renewable and bipotential liver stem cells exist in development, homeostasis, regeneration, and disease.

Mesh：

Year: 2014 PMID： 24792114 DOI： 10.1016/j.stem.2014.04.010

Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633

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Cited

195 in total

1. Regenerative biology: Maintaining liver mass.

Authors: Kenneth S Zaret
Journal: Nature Date: 2015-08-05 Impact factor: 49.962

2. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer.

Authors: Joan Font-Burgada; Shabnam Shalapour; Suvasini Ramaswamy; Brian Hsueh; David Rossell; Atsushi Umemura; Koji Taniguchi; Hayato Nakagawa; Mark A Valasek; Li Ye; Janel L Kopp; Maike Sander; Hannah Carter; Karl Deisseroth; Inder M Verma; Michael Karin
Journal: Cell Date: 2015-08-13 Impact factor: 41.582

Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming.

1. Regenerative biology: Maintaining liver mass.

2. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer.

3. Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture.

Review 4. Cellular homeostasis and repair in the mammalian liver.

5. Thymic NF-κB-inducing kinase regulates CD4⁺ T cell-elicited liver injury and fibrosis in mice.

6. miR-206 inhibits liver cancer stem cell expansion by regulating EGFR expression.

7. HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers.

Review 8. Emerging advancements in liver regeneration and organogenesis as tools for liver replacement.

9. Lineage fate of ductular reactions in liver injury and carcinogenesis.

10. Egf Signaling Directs Neoblast Repopulation by Regulating Asymmetric Cell Division in Planarians.