Literature DB >> 27308519

Unraveling the therapeutic potential of the LncRNA-dependent noncanonical Hedgehog pathway in cancer.

Zhen Xing1, Chunru Lin2, Liuqing Yang3.   

Abstract

Acquired resistance to Hedgehog pathway inhibitors has been reported in the clinical setting and upregulation of noncanonical Hedgehog signaling is one of the major underlying mechanisms behind this resistance. As demonstrated in our recent study, greater clinical efficacy might be achieved by focusing on downstream targets of the chemokine-activated noncanonical Hedgehog signaling pathway such as BCAR4 and phospho-GLI2 (Ser149).

Entities:  

Keywords:  BCAR4; Hedgehog Gli2; Long non-coding RNA; breast cancer; cancer treatment; locked nucleic acid; lung metastasis; signaling pathway

Year:  2015        PMID： 27308519      PMCID： PMC4905365          DOI： 10.1080/23723556.2014.998900

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  7 in total

1.  Clinical experience with Hedgehog pathway inhibitors.

Authors:  Jennifer A Low; Frederic J de Sauvage
Journal:  J Clin Oncol       Date:  2010-11-01       Impact factor: 44.544

Review 2.  Unraveling the therapeutic potential of the Hedgehog pathway in cancer.

Authors:  Dereck Amakye; Zainab Jagani; Marion Dorsch
Journal:  Nat Med       Date:  2013-11-07       Impact factor: 53.440

3.  lncRNA directs cooperative epigenetic regulation downstream of chemokine signals.

Authors:  Zhen Xing; Aifu Lin; Chunlai Li; Ke Liang; Shouyu Wang; Yang Liu; Peter K Park; Li Qin; Yongkun Wei; David H Hawke; Mien-Chie Hung; Chunru Lin; Liuqing Yang
Journal:  Cell       Date:  2014-11-13       Impact factor: 41.582

Review 4.  RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts.

Authors:  Sarah Geisler; Jeff Coller
Journal:  Nat Rev Mol Cell Biol       Date:  2013-10-09       Impact factor: 94.444

Review 5.  Long noncoding RNAs and prostate carcinogenesis: the missing 'linc'?

Authors:  Anna L Walsh; Alexandra V Tuzova; Eva M Bolton; Thomas H Lynch; Antoinette S Perry
Journal:  Trends Mol Med       Date:  2014-05-13       Impact factor: 11.951

6.  Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.

Authors:  Daniel D Von Hoff; Patricia M LoRusso; Charles M Rudin; Josina C Reddy; Robert L Yauch; Raoul Tibes; Glen J Weiss; Mitesh J Borad; Christine L Hann; Julie R Brahmer; Howard M Mackey; Bertram L Lum; Walter C Darbonne; James C Marsters; Frederic J de Sauvage; Jennifer A Low
Journal:  N Engl J Med       Date:  2009-09-02       Impact factor: 91.245

7.  Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia.

Authors:  Thomas Trimarchi; Erhan Bilal; Panagiotis Ntziachristos; Giulia Fabbri; Riccardo Dalla-Favera; Aristotelis Tsirigos; Iannis Aifantis
Journal:  Cell       Date:  2014-07-31       Impact factor: 41.582
  7 in total
  3 in total

1.  Long non-coding RNAs as novel biomarkers for breast cancer invasion and metastasis.

Authors:  Kaijiong Zhang; Zhenglian Luo; Yi Zhang; Xiaoyu Song; Li Zhang; Lichun Wu; Jinbo Liu
Journal:  Oncol Lett       Date:  2017-06-22       Impact factor: 2.967

Review 2.  Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers.

Authors:  Guillaume Latgé; Christophe Poulet; Vincent Bours; Claire Josse; Guy Jerusalem
Journal:  Int J Mol Sci       Date:  2018-01-02       Impact factor: 5.923

3.  Long Noncoding RNA DIO3OS Hinders Cell Malignant Behaviors of Hepatocellular Carcinoma Cells Through the microRNA-328/Hhip Axis.

Authors:  Zhanpeng Wang; Lina Song; Yanshuo Ye; Wei Li
Journal:  Cancer Manag Res       Date:  2020-05-25       Impact factor: 3.989
  3 in total

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