Literature DB >> 27308447

OPA1 and mitochondrial solute carriers in bioenergetic metabolism.

Marc Germain1.   

Abstract

The mitochondrial fusion protein optic atrophy 1 (OPA1) is required to maintain cristae structure and for ATP synthase assembly. Our recent work demonstrates that OPA1 dynamically regulates these processes by sensing changes in nutrient availability through mitochondrial solute carriers and adjusting the metabolic output of mitochondria accordingly. This is a critical survival process as its inhibition leads to cell death.

Entities:  

Keywords:  ATP synthase; OPA1; SLC25A; apoptosis; autophagy; metabolic regulation; mitochondria; mitochondrial cristae

Year:  2015        PMID： 27308447      PMCID： PMC4904881          DOI： 10.4161/23723556.2014.982378

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.

Authors:  Marc Germain; Jaigi P Mathai; Heidi M McBride; Gordon C Shore
Journal:  EMBO J       Date:  2005-03-24       Impact factor: 11.598

Review 2.  Structure and dynamics of the mitochondrial inner membrane cristae.

Authors:  Carmen A Mannella
Journal:  Biochim Biophys Acta       Date:  2006-04-20

Review 3.  The mitochondrial transporter family SLC25: identification, properties and physiopathology.

Authors:  Ferdinando Palmieri
Journal:  Mol Aspects Med       Date:  2012-12-23

4.  Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation.

Authors:  Angelika S Rambold; Brenda Kostelecky; Natalie Elia; Jennifer Lippincott-Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-06       Impact factor: 11.205

5.  Ultrastructural bases for metabolically linked mechanical activity in mitochondria. I. Reversible ultrastructural changes with change in metabolic steady state in isolated liver mitochondria.

Authors:  C R Hackenbrock
Journal:  J Cell Biol       Date:  1966-08       Impact factor: 10.539

6.  OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.

Authors:  David A Patten; Jacob Wong; Mireille Khacho; Vincent Soubannier; Ryan J Mailloux; Karine Pilon-Larose; Jason G MacLaurin; David S Park; Heidi M McBride; Laura Trinkle-Mulcahy; Mary-Ellen Harper; Marc Germain; Ruth S Slack
Journal:  EMBO J       Date:  2014-10-08       Impact factor: 11.598

Review 7.  The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.

Authors:  Ralph J DeBerardinis; Julian J Lum; Georgia Hatzivassiliou; Craig B Thompson
Journal:  Cell Metab       Date:  2008-01       Impact factor: 27.287

Review 8.  Mitochondria: from cell death executioners to regulators of cell differentiation.

Authors:  Atsuko Kasahara; Luca Scorrano
Journal:  Trends Cell Biol       Date:  2014-09-02       Impact factor: 20.808

9.  Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency.

Authors:  Sara Cogliati; Christian Frezza; Maria Eugenia Soriano; Tatiana Varanita; Ruben Quintana-Cabrera; Mauro Corrado; Sara Cipolat; Veronica Costa; Alberto Casarin; Ligia C Gomes; Ester Perales-Clemente; Leonardo Salviati; Patricio Fernandez-Silva; Jose A Enriquez; Luca Scorrano
Journal:  Cell       Date:  2013-09-19       Impact factor: 41.582

Review 10.  Emerging regulation and functions of autophagy.

Authors:  Patricia Boya; Fulvio Reggiori; Patrice Codogno
Journal:  Nat Cell Biol       Date:  2013-07       Impact factor: 28.824
  10 in total
  1 in total

1.  Novel insights into SLC25A46-related pathologies in a genetic mouse model.

Authors:  Maria Eirini Terzenidou; Aikaterini Segklia; Toshimi Kano; Florentia Papastefanaki; Alexandros Karakostas; Maria Charalambous; Fotis Ioakeimidis; Maria Papadaki; Ismini Kloukina; Margarita Chrysanthou-Piterou; Martina Samiotaki; George Panayotou; Rebecca Matsas; Eleni Douni
Journal:  PLoS Genet       Date:  2017-04-04       Impact factor: 5.917
  1 in total

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