Zhijian Hu1, Ruimin Chen2, Chunyan Cai2. 1. Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment factors and Cancer, School of Public Health, Fujian Medical University, Fujian, China. 2. Department of Endocrinology, Fuzhou Children's Hospital of Fujian, Teaching Hospital of Fujian Medical University, Fujian, China.
Abstract
BACKGROUND: Genome-wide association studies have identified rs314276, rs314263, rs7759938, and rs314280 in or near the LIN28B gene as associated with age at menarche. To date, the effect of polymorphisms in this gene on idiopathic central precocious puberty (ICPP) in Chinese girls have not been reported. The aim of this study was to evaluate the association of the four loci with ICPP in Chinese girls. METHODS: In this study, we conducted a case-control study including 502 girls with ICPP and 489 controls. Four single-nucleotide polymorphisms (SNPs) were genotyped in both groups using an improved multiplex ligation detection reaction (iMLDR) technique. RESULTS: Of the four SNPs of the LIN28B analyzed, three SNPs, rs314276, rs7759938, and rs314280, were associated with ICPP risk at P < 0.05. The association of rs314276, however, was no longer significant after adjustment for multiple testing. Compared with rs7759938 TT or TC genotype, decreased ICPP risk was associated with CC (OR = 0.527, 95% CI: 0.329-0.843) genotype (P = 0.008). Compared with rs314280 GG or GA genotype, decreased ICPP risk was associated with minor allele carrier (AA) genotype (OR = 0.538, 95% CI: 0.337-0.858, P = 0.009). The two identified variants showed the same association signals for ICPP. CONCLUSION: In conclusion, common genetic variations (rs7759938 and rs314280) of LIN28B may contribute to ICPP susceptibility in Chinese girls.
BACKGROUND: Genome-wide association studies have identified rs314276, rs314263, rs7759938, and rs314280 in or near the LIN28B gene as associated with age at menarche. To date, the effect of polymorphisms in this gene on idiopathic central precocious puberty (ICPP) in Chinese girls have not been reported. The aim of this study was to evaluate the association of the four loci with ICPP in Chinese girls. METHODS: In this study, we conducted a case-control study including 502 girls with ICPP and 489 controls. Four single-nucleotide polymorphisms (SNPs) were genotyped in both groups using an improved multiplex ligation detection reaction (iMLDR) technique. RESULTS: Of the four SNPs of the LIN28B analyzed, three SNPs, rs314276, rs7759938, and rs314280, were associated with ICPP risk at P < 0.05. The association of rs314276, however, was no longer significant after adjustment for multiple testing. Compared with rs7759938 TT or TC genotype, decreased ICPP risk was associated with CC (OR = 0.527, 95% CI: 0.329-0.843) genotype (P = 0.008). Compared with rs314280 GG or GA genotype, decreased ICPP risk was associated with minor allele carrier (AA) genotype (OR = 0.538, 95% CI: 0.337-0.858, P = 0.009). The two identified variants showed the same association signals for ICPP. CONCLUSION: In conclusion, common genetic variations (rs7759938 and rs314280) of LIN28B may contribute to ICPP susceptibility in Chinese girls.
Authors: Ken K Ong; Cathy E Elks; Andrew K Wills; Andrew Wong; Nicholas J Wareham; Ruth J F Loos; Diana Kuh; Rebecca Hardy Journal: J Clin Endocrinol Metab Date: 2010-10-20 Impact factor: 5.958
Authors: Chunyan He; Peter Kraft; Constance Chen; Julie E Buring; Guillaume Paré; Susan E Hankinson; Stephen J Chanock; Paul M Ridker; David J Hunter; Daniel I Chasman Journal: Nat Genet Date: 2009-05-17 Impact factor: 38.330
Authors: Sung Won Park; Seung-Tae Lee; Young Bae Sohn; Sung Yoon Cho; Se-Hwa Kim; Su Jin Kim; Chi Hwa Kim; Ah-Ra Ko; Kyung-Hoon Paik; Jong-Won Kim; Dong-Kyu Jin Journal: Korean J Pediatr Date: 2012-10-29