BACKGROUND: Age of menarche, or the timing of first menses in girls, is a physiological trait that shows substantial genetic heritability. Earlier age of menarche is associated with increased childhood adiposity and with adult risk of obesity and cardiovascular disease. OBJECTIVES: We sought to further characterize the single nucleotide polymorphism (SNP) rs7759938 from the menarche locus LIN28B in 827 young Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). METHODS: We tested rs7759938 for additive association with age of menarche and also tested whether childhood adiposity, as measured by body mass index (BMI) at age 8, mediated this relationship. RESULTS: We observed nominal association of rs7759938 with age of menarche (β = -0.118 years, 95% confidence interval = (-0.216, -0.020), P = 0.019) with an effect direction consistent with the previous report. We also observed suggestive evidence that the effect of the SNP on age of menarche was independent of childhood BMI. CONCLUSIONS: These data confirm the strongest gene reported in Europeans (LIN28B) as a contributor to age of menarche in an Asian population.
BACKGROUND: Age of menarche, or the timing of first menses in girls, is a physiological trait that shows substantial genetic heritability. Earlier age of menarche is associated with increased childhood adiposity and with adult risk of obesity and cardiovascular disease. OBJECTIVES: We sought to further characterize the single nucleotide polymorphism (SNP) rs7759938 from the menarche locus LIN28B in 827 young Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). METHODS: We tested rs7759938 for additive association with age of menarche and also tested whether childhood adiposity, as measured by body mass index (BMI) at age 8, mediated this relationship. RESULTS: We observed nominal association of rs7759938 with age of menarche (β = -0.118 years, 95% confidence interval = (-0.216, -0.020), P = 0.019) with an effect direction consistent with the previous report. We also observed suggestive evidence that the effect of the SNP on age of menarche was independent of childhood BMI. CONCLUSIONS: These data confirm the strongest gene reported in Europeans (LIN28B) as a contributor to age of menarche in an Asian population.
Authors: Elisabeth Widén; Samuli Ripatti; Diana L Cousminer; Ida Surakka; Tuuli Lappalainen; Marjo-Riitta Järvelin; Johan G Eriksson; Olli Raitakari; Veikko Salomaa; Ulla Sovio; Anna-Liisa Hartikainen; Anneli Pouta; Mark I McCarthy; Clive Osmond; Eero Kajantie; Terho Lehtimäki; Jorma Viikari; Mika Kähönen; Chris Tyler-Smith; Nelson Freimer; Joel N Hirschhorn; Leena Peltonen; Aarno Palotie Journal: Am J Hum Genet Date: 2010-04-15 Impact factor: 11.025
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Authors: Jaakko T Leinonen; Ida Surakka; Aki S Havulinna; Johannes Kettunen; Riitta Luoto; Veikko Salomaa; Elisabeth Widén Journal: PLoS One Date: 2012-11-13 Impact factor: 3.240
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