Cristian Rapicetta1, Filippo Lococo2, Alessandro Stefani3, Giulio Rossi4, Tommaso Ricchetti1, Angelina Filice5, Antonella Franceschetto6, Giorgio Treglia7, Massimiliano Paci1. 1. Unit of Thoracic Surgery, Arcispedale Santa Maria Nuova-IRCCS, via Risorgimento 80, 42100, Reggio Emilia, Italy. 2. Unit of Thoracic Surgery, Arcispedale Santa Maria Nuova-IRCCS, via Risorgimento 80, 42100, Reggio Emilia, Italy. filippo_lococo@yahoo.it. 3. Unit of Thoracic Surgery, University of Modena and Reggio Emilia, Modena, Italy. 4. Unit of Pathology, University of Modena and Reggio Emilia, Modena, Italy. 5. Department of Nuclear Medicine, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy. 6. Department of Nuclear Medicine, University of Modena and Reggio Emilia, Modena, Italy. 7. Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
Abstract
INTRODUCTION: Pulmonary sarcomatoid carcinoma (PSC) is a very rare and uninvestigated subtype of non-small cell lung cancer (NSCLC). METHODS: The aims of this study were to define the radiometabolic features (by (18)F-FDG PET/CT) in a bi-centric cohort of 49 PSC patients and to explore their relation with clinico-pathological characteristics and long-term survival results after surgical treatment. RESULTS: There were 40 males and 9 females aged 65.2 ± 10.47 years. Overall long-term survival was 26.7 % at 5 years. Mean and median values of SUVmax were 15.21 and 15, respectively (SD ±5.5). Performing an age-, gender- and staging-matched analysis comparing PSC Stage-I only with a cohort of Stage-I NSCLC (n = 93), we observed significantly higher SUVmax values in PSC group (15.11 vs 7.66, p = 0.001). CONCLUSIONS: No differences in terms of SUVmax were found with regard to tumour dimensions, histology (pure vs mixed, pleomorphic vs others), pathological stage and pattern of recurrence. P-stage, surgical radicality, vascular/lymphatic invasion but not SUVmax affected long-term survival in PSC.
INTRODUCTION:Pulmonary sarcomatoid carcinoma (PSC) is a very rare and uninvestigated subtype of non-small cell lung cancer (NSCLC). METHODS: The aims of this study were to define the radiometabolic features (by (18)F-FDG PET/CT) in a bi-centric cohort of 49 PSC patients and to explore their relation with clinico-pathological characteristics and long-term survival results after surgical treatment. RESULTS: There were 40 males and 9 females aged 65.2 ± 10.47 years. Overall long-term survival was 26.7 % at 5 years. Mean and median values of SUVmax were 15.21 and 15, respectively (SD ±5.5). Performing an age-, gender- and staging-matched analysis comparing PSC Stage-I only with a cohort of Stage-I NSCLC (n = 93), we observed significantly higher SUVmax values in PSC group (15.11 vs 7.66, p = 0.001). CONCLUSIONS: No differences in terms of SUVmax were found with regard to tumour dimensions, histology (pure vs mixed, pleomorphic vs others), pathological stage and pattern of recurrence. P-stage, surgical radicality, vascular/lymphatic invasion but not SUVmax affected long-term survival in PSC.
Authors: Nikolaos E Makris; Marc C Huisman; Paul E Kinahan; Adriaan A Lammertsma; Ronald Boellaard Journal: Eur J Nucl Med Mol Imaging Date: 2013-06-11 Impact factor: 9.236