Literature DB >> 27299507

Systemic Delivery and Biodistribution of Cisplatin in Vivo.

Yu-Hsuan Chu1, Martha Sibrian-Vazquez1, Jorge O Escobedo1, Amanda R Phillips, D Thomas Dickey, Qi Wang, Martina Ralle, Peter S Steyger, Robert M Strongin1.   

Abstract

Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin's off-target effects, a new drug-fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.

Entities:  

Keywords:  Texas Red; cisplatin; conjugate; ototoxicity; tracer

Mesh：

Substances：

Year:  2016        PMID： 27299507      PMCID： PMC5017860          DOI： 10.1021/acs.molpharmaceut.6b00240

Source DB:  PubMed          Journal:  Mol Pharm        ISSN： 1543-8384            Impact factor:   4.939


  30 in total

1.  A systemic gentamicin pathway across the stria vascularis.

Authors:  Chun Fu Dai; Peter S Steyger
Journal:  Hear Res       Date:  2007-11-17       Impact factor: 3.208

2.  Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.

Authors:  Giuliano Ciarimboli; Dirk Deuster; Arne Knief; Michael Sperling; Michael Holtkamp; Bayram Edemir; Hermann Pavenstädt; Claudia Lanvers-Kaminsky; Antoinette am Zehnhoff-Dinnesen; Alfred H Schinkel; Hermann Koepsell; Heribert Jürgens; Eberhard Schlatter
Journal:  Am J Pathol       Date:  2010-01-28       Impact factor: 4.307

3.  Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy.

Authors:  Abhimanyu S Paraskar; Shivani Soni; Kenneth T Chin; Padmaparna Chaudhuri; Katherine W Muto; Julia Berkowitz; Michael W Handlogten; Nathan J Alves; Basar Bilgicer; Daniela M Dinulescu; Raghunath A Mashelkar; Shiladitya Sengupta
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-23       Impact factor: 11.205

4.  Early changes in auditory function as a result of platinum chemotherapy: use of extended high-frequency audiometry and evoked distortion product otoacoustic emissions.

Authors:  Kristin R Knight; Dale F Kraemer; Christiane Winter; Edward A Neuwelt
Journal:  J Clin Oncol       Date:  2007-04-01       Impact factor: 44.544

5.  Pharmacokinetics of cisplatin in analbuminemic rats.

Authors:  K Takada; T Kawamura; M Inai; S Masuda; T Oka; Y Yoshikawa; N Shibata; H Yoshikawa; O Ike; H Wada; S Hitomi
Journal:  Biopharm Drug Dispos       Date:  1999-12       Impact factor: 1.627

6.  Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity.

Authors:  Ja-Won Koo; Lourdes Quintanilla-Dieck; Meiyan Jiang; Jianping Liu; Zachary D Urdang; Jordan J Allensworth; Campbell P Cross; Hongzhe Li; Peter S Steyger
Journal:  Sci Transl Med       Date:  2015-07-29       Impact factor: 17.956

7.  Ototoxicity, nephrotoxicity and pharmacokinetics of cisplatin and its monohydrated complex in the guinea pig.

Authors:  Andreas Ekborn; Annika Lindberg; Göran Laurell; Inger Wallin; Staffan Eksborg; Hans Ehrsson
Journal:  Cancer Chemother Pharmacol       Date:  2002-11-02       Impact factor: 3.333

Review 8.  The resurgence of platinum-based cancer chemotherapy.

Authors:  Lloyd Kelland
Journal:  Nat Rev Cancer       Date:  2007-07-12       Impact factor: 60.716

9.  Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells.

Authors:  Qi Wang; Peter S Steyger
Journal:  J Assoc Res Otolaryngol       Date:  2009-03-03

10.  Identification of cisplatin-binding proteins using agarose conjugates of platinum compounds.

Authors:  Takatoshi Karasawa; Martha Sibrian-Vazquez; Robert M Strongin; Peter S Steyger
Journal:  PLoS One       Date:  2013-06-03       Impact factor: 3.240
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  7 in total

1.  Lovastatin protects against cisplatin-induced hearing loss in mice.

Authors:  Katharine Fernandez; Katie K Spielbauer; Aaron Rusheen; Lizhen Wang; Tiffany G Baker; Stephen Eyles; Lisa L Cunningham
Journal:  Hear Res       Date:  2020-02-06       Impact factor: 3.208

2.  Cool OtOprotective Ear Lumen (COOL) Therapy for Cisplatin-induced Hearing Loss.

Authors:  James K Stanford; Drew S Morgan; Nicholas A Bosworth; Georgio Proctor; Tianwen Chen; Trace T Palmer; Punam Thapa; Bradley J Walters; Douglas E Vetter; Robert D Black; Lesco L Rogers; Christopher Spankovich
Journal:  Otol Neurotol       Date:  2021-03-01       Impact factor: 2.311

3.  The Mechanotransduction Channel and Organic Cation Transporter Are Critical for Cisplatin Ototoxicity in Murine Hair Cells.

Authors:  Jinan Li; Chang Liu; Samuel Kaefer; Mariam Youssef; Bo Zhao
Journal:  Front Mol Neurosci       Date:  2022-02-10       Impact factor: 6.261

Review 4.  Modulating biomolecular condensates: a novel approach to drug discovery.

Authors:  Diana M Mitrea; Matthäus Mittasch; Beatriz Ferreira Gomes; Isaac A Klein; Mark A Murcko
Journal:  Nat Rev Drug Discov       Date:  2022-08-16       Impact factor: 112.288

5.  Chronic suppurative otitis media causes macrophage-associated sensorineural hearing loss.

Authors:  Anping Xia; Anthony Thai; Zhixin Cao; Xiaohua Chen; Jing Chen; Brian Bacacao; Laurent A Bekale; Viktoria Schiel; Paul L Bollyky; Peter L Santa Maria
Journal:  J Neuroinflammation       Date:  2022-09-12       Impact factor: 9.587

6.  Bone-Marrow-Derived Mesenchymal Stem Cells, Their Conditioned Media, and Olive Leaf Extract Protect against Cisplatin-Induced Toxicity by Alleviating Oxidative Stress, Inflammation, and Apoptosis in Rats.

Authors:  Mahrous A Ibrahim; Athar M Khalifa; Alaa A Mohamed; Rania A Galhom; Horeya E Korayem; Noha M Abd El-Fadeal; Ahmed Abd-Eltawab Tammam; Mohamed Mansour Khalifa; Osama S Elserafy; Rehab I Abdel-Karim
Journal:  Toxics       Date:  2022-09-06

Review 7.  Preferential Cochleotoxicity of Cisplatin.

Authors:  Pattarawadee Prayuenyong; David M Baguley; Corné J Kros; Peter S Steyger
Journal:  Front Neurosci       Date:  2021-07-26       Impact factor: 4.677
  7 in total

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