Literature DB >> 27291650

Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.

Qiang Zhang1, Lei Zeng1, Chen Shen2, Ying Ju3, Tsuyoshi Konuma4, Chengcheng Zhao3, Christopher R Vakoc5, Ming-Ming Zhou6.   

Abstract

The bromodomains and extra-terminal domain (BET) proteins direct gene transcription in chromatin, and represent new drug targets for cancer and inflammation. Here we report that the ET domain of the BET protein BRD4 recognizes an amphipathic protein sequence motif through establishing a two-strand antiparallel β sheet anchored on a hydrophobic cleft of the three-helix bundle. This structural mechanism likely explains BRD4 interactions with numerous cellular and viral proteins such as Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen, and NSD3 whose interaction with BRD4 via this ET domain mechanism is essential for acute myeloid leukemia maintenance.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27291650      PMCID： PMC4938737          DOI： 10.1016/j.str.2016.04.019

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  23 in total

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Authors:  S Morita; T Kojima; T Kitamura
Journal:  Gene Ther       Date:  2000-06       Impact factor: 5.250

2.  Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction.

Authors:  Brandon L Crowe; Ross C Larue; Chunhua Yuan; Sonja Hess; Mamuka Kvaratskhelia; Mark P Foster
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-08       Impact factor: 11.205

3.  Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression.

Authors:  Mar Gacias; Guillermo Gerona-Navarro; Alexander N Plotnikov; Guangtao Zhang; Lei Zeng; Jasbir Kaur; Gregory Moy; Elena Rusinova; Yoel Rodriguez; Bridget Matikainen; Adam Vincek; Jennifer Joshua; Patrizia Casaccia; Ming-Ming Zhou
Journal:  Chem Biol       Date:  2014-06-19

4.  Crystallography & NMR system: A new software suite for macromolecular structure determination.

Authors:  A T Brünger; P D Adams; G M Clore; W L DeLano; P Gros; R W Grosse-Kunstleve; J S Jiang; J Kuszewski; M Nilges; N S Pannu; R J Read; L M Rice; T Simonson; G L Warren
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1998-09-01

Review 5.  Multidimensional heteronuclear nuclear magnetic resonance of proteins.

Authors:  G M Clore; A M Gronenborn
Journal:  Methods Enzymol       Date:  1994       Impact factor: 1.600

6.  Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

Authors:  Sebastian Schröder; Sungyoo Cho; Lei Zeng; Qiang Zhang; Katrin Kaehlcke; Lily Mak; Joann Lau; Dwayne Bisgrove; Martina Schnölzer; Eric Verdin; Ming-Ming Zhou; Melanie Ott
Journal:  J Biol Chem       Date:  2011-11-14       Impact factor: 5.157

7.  The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

Authors:  Shaila Rahman; Mathew E Sowa; Matthias Ottinger; Jennifer A Smith; Yang Shi; J Wade Harper; Peter M Howley
Journal:  Mol Cell Biol       Date:  2011-05-09       Impact factor: 4.272

8.  Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4.

Authors:  Cheng-Ming Chiang
Journal:  F1000 Biol Rep       Date:  2009-12-15

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  21 in total

Review 1.  Targeting Cancer Cells with BET Bromodomain Inhibitors.

Authors:  Yali Xu; Christopher R Vakoc
Journal:  Cold Spring Harb Perspect Med       Date:  2017-07-05       Impact factor: 6.915

2.  The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.

Authors:  Dorothy C C Wai; Taylor N Szyszka; Amy E Campbell; Cherry Kwong; Lorna E Wilkinson-White; Ana P G Silva; Jason K K Low; Ann H Kwan; Roland Gamsjaeger; James D Chalmers; Wayne M Patrick; Bin Lu; Christopher R Vakoc; Gerd A Blobel; Joel P Mackay
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Journal:  Mol Clin Oncol       Date:  2017-06-08

Review 4.  The Essential Transcriptional Function of BRD4 in Acute Myeloid Leukemia.

Authors:  Jae-Seok Roe; Christopher R Vakoc
Journal:  Cold Spring Harb Symp Quant Biol       Date:  2017-02-07

5.  HDAC11 suppresses the thermogenic program of adipose tissue via BRD2.

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Journal:  JCI Insight       Date:  2018-08-09

Review 6.  Bromodomain biology and drug discovery.

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Journal:  Nat Struct Mol Biol       Date:  2019-10-03       Impact factor: 15.369

7.  Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system.

Authors:  Michael T Werner; Hongxin Wang; Nicole Hamagami; Sarah C Hsu; Jennifer A Yano; Aaron J Stonestrom; Vivek Behera; Yichen Zhong; Joel P Mackay; Gerd A Blobel
Journal:  J Biol Chem       Date:  2019-12-02       Impact factor: 5.157

8.  A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other "Shock" Drugs.

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9.  Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

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Journal:  Mol Cell       Date:  2018-12-13       Impact factor: 17.970

10.  A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins.

Authors:  Sriram Aiyer; G V T Swapna; Li-Chung Ma; Gaohua Liu; Jingzhou Hao; Gordon Chalmers; Brian C Jacobs; Gaetano T Montelione; Monica J Roth
Journal:  Structure       Date:  2021-02-15       Impact factor: 5.006
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