Cássia Fernanda Estofolete1, Ana Carolina Bernardes Terzian2, Ricardo Parreira3, Aida Esteves4, Lucas Hardman5, Gilmar Valdir Greque6, Paula Rahal7, Maurício Lacerda Nogueira8. 1. São José do Rio Preto School of Medicine (FAMERP), Avenida Brigadeiro Faria Lima, 5416. Vila São Pedro. São José do Rio Preto, CEP: 15090-000, SP, Brazil. Electronic address: cassiafestofolete@gmail.com. 2. São José do Rio Preto School of Medicine (FAMERP), Avenida Brigadeiro Faria Lima, 5416. Vila São Pedro. São José do Rio Preto, CEP: 15090-000, SP, Brazil. Electronic address: anacarolinaterzian@gmail.com. 3. Global Health and Tropical Medicine (GHTM), Universidade Nova de Lisboa, Rua da Junqueira Nº 100, 1349-008 Lisboa, Portugal. Electronic address: ricardo@ihmt.unl.pt. 4. Global Health and Tropical Medicine (GHTM), Universidade Nova de Lisboa, Rua da Junqueira Nº 100, 1349-008 Lisboa, Portugal. Electronic address: aidaesteves@ihmt.unl.pt. 5. São José do Rio Preto School of Medicine (FAMERP), Avenida Brigadeiro Faria Lima, 5416. Vila São Pedro. São José do Rio Preto, CEP: 15090-000, SP, Brazil. Electronic address: lucashardman@hotmail.com. 6. São José do Rio Preto Regional School of Medicine Foundation (FUNFARME), Avenida Brigadeiro Faria Lima, 5416. Vila São Pedro. São José do Rio Preto, SP, CEP: 15090-000, Brazil. Electronic address: greque@terra.com.br. 7. Department of Biology, Institute of Biosciences, Letters, and Exact Sciences - São Paulo State University, São José do Rio Preto - (IBILCE/UNESP), Rua Cristóvão Colombo, 2265, CEP: 15054-000 - São José do Rio Preto, SP, Brazil. Electronic address: rahalp@yahoo.com.br. 8. São José do Rio Preto School of Medicine (FAMERP), Avenida Brigadeiro Faria Lima, 5416. Vila São Pedro. São José do Rio Preto, CEP: 15090-000, SP, Brazil. Electronic address: mnogueira@famerp.br.
Abstract
BACKGROUND: The Zika virus (ZIKV) is an emerging arthropod-borne virus related to the dengue virus (DENV), and shows a similar clinical profile as other arboviral diseases, such as dengue and chikungunya virus (CHIKV). Historically, ZIKV has been associated with sporadic cases of human infection, but is now responsible for outbreaks worldwide. In Brazil, cases have been reported since 2015, with some cases causing severe disease. OBJECTIVE: To identify clinical symptoms of Zika in patients in Dengue suspected patients. STUDY DESIGN: Description of a series of cases, wherein we analyzed 100 clinical samples collected from patients who exhibited acute febrile disease for ≤5days, from January to February 2016. RESULTS: In this study, we report 13 cases of ZIKV infection in adults presenting dengue-like symptoms in a DENV endemic area. All patients presented with fever, with myalgia being the second most frequently observed symptom. Two patients had rashes, but none of them had conjunctivitis. Other less frequent manifestations included headache, arthralgia, diarrhea, and nausea. CONCLUSION: The co-circulation of ZIKV and DENV is a serious public health concern, since it represents both a clinical and diagnostic challenge in endemic areas, as well as in the field of travel medicine.
BACKGROUND: The Zika virus (ZIKV) is an emerging arthropod-borne virus related to the dengue virus (DENV), and shows a similar clinical profile as other arboviral diseases, such as dengue and chikungunya virus (CHIKV). Historically, ZIKV has been associated with sporadic cases of humaninfection, but is now responsible for outbreaks worldwide. In Brazil, cases have been reported since 2015, with some cases causing severe disease. OBJECTIVE: To identify clinical symptoms of Zika in patients in Dengue suspected patients. STUDY DESIGN: Description of a series of cases, wherein we analyzed 100 clinical samples collected from patients who exhibited acute febrile disease for ≤5days, from January to February 2016. RESULTS: In this study, we report 13 cases of ZIKV infection in adults presenting dengue-like symptoms in a DENV endemic area. All patients presented with fever, with myalgia being the second most frequently observed symptom. Two patients had rashes, but none of them had conjunctivitis. Other less frequent manifestations included headache, arthralgia, diarrhea, and nausea. CONCLUSION: The co-circulation of ZIKV and DENV is a serious public health concern, since it represents both a clinical and diagnostic challenge in endemic areas, as well as in the field of travel medicine.
Authors: Irene Bosch; Helena de Puig; Megan Hiley; Marc Carré-Camps; Federico Perdomo-Celis; Carlos F Narváez; Doris M Salgado; Dewahar Senthoor; Madeline O'Grady; Elizabeth Phillips; Ann Durbin; Diana Fandos; Hikaru Miyazaki; Chun-Wan Yen; Margarita Gélvez-Ramírez; Rajas V Warke; Lucas S Ribeiro; Mauro M Teixeira; Roque P Almeida; José E Muñóz-Medina; Juan E Ludert; Mauricio L Nogueira; Tatiana E Colombo; Ana C B Terzian; Patricia T Bozza; Andrea S Calheiros; Yasmine R Vieira; Giselle Barbosa-Lima; Alexandre Vizzoni; José Cerbino-Neto; Fernando A Bozza; Thiago M L Souza; Monique R O Trugilho; Ana M B de Filippis; Patricia C de Sequeira; Ernesto T A Marques; Tereza Magalhaes; Francisco J Díaz; Berta N Restrepo; Katerine Marín; Salim Mattar; Daniel Olson; Edwin J Asturias; Mark Lucera; Mohit Singla; Guruprasad R Medigeshi; Norma de Bosch; Justina Tam; Jose Gómez-Márquez; Charles Clavet; Luis Villar; Kimberly Hamad-Schifferli; Lee Gehrke Journal: Sci Transl Med Date: 2017-09-27 Impact factor: 17.956
Authors: Kartikeya Cherabuddi; Nicole M Iovine; Kairav Shah; Sarah K White; Taylor Paisie; Marco Salemi; J Glenn Morris; John A Lednicky Journal: JMM Case Rep Date: 2016-12-19
Authors: Cássia F Estofolete; Bruno H G A Milhim; Nathalia Zini; Samuel N Scamardi; Joana D'Arc Selvante; Nikos Vasilakis; Maurício L Nogueira Journal: Viruses Date: 2020-06-22 Impact factor: 5.048
Authors: Alice F Versiani; Estefânia M N Martins; Lidia M Andrade; Laura Cox; Glauco C Pereira; Edel F Barbosa-Stancioli; Mauricio L Nogueira; Luiz O Ladeira; Flávio G da Fonseca Journal: Sci Rep Date: 2020-07-09 Impact factor: 4.379