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Literature DB >> 27284591

A click chemistry-based microRNA maturation assay optimized for high-throughput screening.

Abstract

Catalytic enzyme-linked click-chemistry assays (cat-ELCCA) are an emerging class of biochemical assay. Herein we report on expanding the toolkit of cat-ELCCA to include the kinetically superior inverse-electron demand Diels-Alder (IEDDA) reaction. The result is a technology with improved sensitivity and reproducibility, enabling automated high-throughput screening.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
MicroRNAs

Year: 2016 PMID： 27284591 PMCID： PMC4919152 DOI： 10.1039/c6cc02894b

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

19 in total

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Authors:
Journal: J Biomol Screen Date: 1999

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Authors: F A Tanious; J M Veal; H Buczak; L S Ratmeyer; W D Wilson
Journal: Biochemistry Date: 1992-03-31 Impact factor: 3.162

Review 3. Recent advances in developing small molecules targeting RNA.

Authors: Lirui Guan; Matthew D Disney
Journal: ACS Chem Biol Date: 2012-01-12 Impact factor: 5.100

4. A small molecule antagonist of ghrelin O-acyltransferase (GOAT).

Authors: Amanda L Garner; Kim D Janda
Journal: Chem Commun (Camb) Date: 2011-05-19 Impact factor: 6.222

Review 5. Therapeutic targeting of microRNAs: current status and future challenges.

Authors: Zhonghan Li; Tariq M Rana
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7. Biomedical applications of tetrazine cycloadditions.

Authors: Neal K Devaraj; Ralph Weissleder
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9. Most mammalian mRNAs are conserved targets of microRNAs.

Authors: Robin C Friedman; Kyle Kai-How Farh; Christopher B Burge; David P Bartel
Journal: Genome Res Date: 2008-10-27 Impact factor: 9.043

10. Bioorthogonal reactions for labeling proteins.

Authors: Kathrin Lang; Jason W Chin
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