| Literature DB >> 27281573 |
Maria A Spyrou1, Rezeda I Tukhbatova2, Michal Feldman1, Joanna Drath3, Sacha Kacki4, Julia Beltrán de Heredia5, Susanne Arnold6, Airat G Sitdikov2, Dominique Castex4, Joachim Wahl7, Ilgizar R Gazimzyanov8, Danis K Nurgaliev9, Alexander Herbig10, Kirsten I Bos11, Johannes Krause12.
Abstract
Ancient DNA analysis has revealed an involvement of the bacterial pathogen Yersinia pestis in several historical pandemics, including the second plague pandemic (Europe, mid-14(th) century Black Death until the mid-18(th) century AD). Here we present reconstructed Y. pestis genomes from plague victims of the Black Death and two subsequent historical outbreaks spanning Europe and its vicinity, namely Barcelona, Spain (1300-1420 cal AD), Bolgar City, Russia (1362-1400 AD), and Ellwangen, Germany (1485-1627 cal AD). Our results provide support for (1) a single entry of Y. pestis in Europe during the Black Death, (2) a wave of plague that traveled toward Asia to later become the source population for contemporary worldwide epidemics, and (3) the presence of an historical European plague focus involved in post-Black Death outbreaks that is now likely extinct.Entities:
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Year: 2016 PMID： 27281573 DOI： 10.1016/j.chom.2016.05.012
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023