Konghow Lee1, Masao Daimon2, Youichi Kuwabara1, Rei Hasegawa1, Tomohiko Toyoda1, Tai Sekine1, Takayuki Kawata1, Issei Komuro1. 1. Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan. 2. Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan. mdaimon@juntendo.ac.jp.
Abstract
BACKGROUND: In this study, we aimed to compare low-dose dobutamine stress echocardiography (DSE) and iodine 123-metaiodobenzylguanidine (MIBG) scintigraphy for predicting the response to beta-blocker therapy in patients with dilated cardiomyopathy (DCM). METHODS: MIBG imaging was performed in 10 patients with DCM (mean EF 28 ± 8%), who were subsequently treated with beta-blocker therapy. The heart-to-mediastinum (H/M) MIBG uptake ratio was evaluated in initial and delayed images, and the percent washout ratio of myocardial MIBG was determined. DSE was also performed in all patients to measure left ventricular ejection fraction (LVEF) at rest and during dobutamine infusion (10 μg/kg/min). LVEF at rest was also assessed by echocardiography before and after 6 months of beta-blocker therapy. RESULTS: LVEF was significantly improved after beta-blocker therapy (28 ± 8 to 41 ± 11%, p < 0.001). The relative change in LVEF after beta-blocker therapy was significantly correlated with the relative change in LVEF during DSE (r = 0.68, p < 0.03). The H/M MIBG uptake ratio in both early and delayed imaging was not significantly correlated with the relative change in LVEF in response to beta-blockade therapy. CONCLUSIONS: The relative change in LVEF during DSE, but not MIBG imaging predicted the relative change in LVEF in response to beta-blockade therapy in a limited number of DCM patients.
BACKGROUND: In this study, we aimed to compare low-dose dobutamine stress echocardiography (DSE) and iodine 123-metaiodobenzylguanidine (MIBG) scintigraphy for predicting the response to beta-blocker therapy in patients with dilated cardiomyopathy (DCM). METHODS:MIBG imaging was performed in 10 patients with DCM (mean EF 28 ± 8%), who were subsequently treated with beta-blocker therapy. The heart-to-mediastinum (H/M) MIBG uptake ratio was evaluated in initial and delayed images, and the percent washout ratio of myocardial MIBG was determined. DSE was also performed in all patients to measure left ventricular ejection fraction (LVEF) at rest and during dobutamine infusion (10 μg/kg/min). LVEF at rest was also assessed by echocardiography before and after 6 months of beta-blocker therapy. RESULTS: LVEF was significantly improved after beta-blocker therapy (28 ± 8 to 41 ± 11%, p < 0.001). The relative change in LVEF after beta-blocker therapy was significantly correlated with the relative change in LVEF during DSE (r = 0.68, p < 0.03). The H/M MIBG uptake ratio in both early and delayed imaging was not significantly correlated with the relative change in LVEF in response to beta-blockade therapy. CONCLUSIONS: The relative change in LVEF during DSE, but not MIBG imaging predicted the relative change in LVEF in response to beta-blockade therapy in a limited number of DCMpatients.
Authors: P Merlet; C Benvenuti; D Moyse; F Pouillart; J L Dubois-Randé; A M Duval; D Loisance; A Castaigne; A Syrota Journal: J Nucl Med Date: 1999-06 Impact factor: 10.057
Authors: T Yamada; M Fukunami; M Ohmori; K Iwakura; K Kumagai; N Kondoh; T Minamino; E Tsujimura; T Nagareda; K Kotoh Journal: J Am Coll Cardiol Date: 1993-03-01 Impact factor: 24.094
Authors: E B Henderson; J K Kahn; J R Corbett; D E Jansen; J J Pippin; P Kulkarni; V Ugolini; M S Akers; C Hansen; L M Buja Journal: Circulation Date: 1988-11 Impact factor: 29.690