Marco Lamberti1,2, Rosamaria Siracusano3, Domenico Italiano4, Norma Alosi5, Francesca Cucinotta5, Gabriella Di Rosa5, Eva Germanò5, Edoardo Spina4, Antonella Gagliano5. 1. Division of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Policlinico Universitario G. Martino, Via Consolare Valeria 1, 98125, Messina, Italy. mlamberti@unime.it. 2. Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. mlamberti@unime.it. 3. Institution of Clinical Physiology, CNR, Messina, Italy. 4. Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. 5. Division of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Policlinico Universitario G. Martino, Via Consolare Valeria 1, 98125, Messina, Italy.
Abstract
BACKGROUND:Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are frequently overlapping neurodevelopmental disorders. Individuals in whom the disorders are comorbid show more severe impairment because of deficits in the processing of social situations, adaptive functioning, and executive control than individuals with either disorder alone. OBJECTIVE: This open-label pilot study aimed to evaluate and compare the efficacy and tolerability of risperidone and aripiprazole for treating ADHD symptoms in patients with both ASD and ADHD over the course of 24 weeks of treatment. METHODS:Patients (n = 44) were randomly assigned to start treatment with risperidone (22 patients) or aripiprazole (22 patients). Children were evaluated before starting treatment (T0), and after 12 weeks (T1) and 24 weeks (T2) of treatment. At each visit, specific psychiatric clinical scales were administered to assess the efficacy of the two drugs. RESULTS:The mean age was 8.4 ± 2.9 years in the aripiprazole group and 7.8 ± 2.3 years in the risperidone group. A total of 37 children (29 boys and 8 girls) completed the study (18 in the aripiprazole group and 19 in the risperidone group). Aripiprazole and risperidone appeared to have similar benefits in terms of efficacy and tolerability, although there were slight differences between the two drugs. Both groups showed a significant improvement in ADHD symptoms after 24 weeks of treatment (ADHD Rating Scale, Conners Parent Rating Scale-Hyperactivity, and Clinical Global Improvement-Severity Scale). No significant difference between the two drugs on any parameters at 24 weeks were found. Prolactin levels were decreased in the aripiprazole group. Both drugs were well tolerated, with no serious adverse events detected. CONCLUSIONS: Our study confirms the efficacy of both aripiprazole and risperidone in ameliorating ADHD symptoms of children also presenting with ASD.
RCT Entities:
BACKGROUND:Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are frequently overlapping neurodevelopmental disorders. Individuals in whom the disorders are comorbid show more severe impairment because of deficits in the processing of social situations, adaptive functioning, and executive control than individuals with either disorder alone. OBJECTIVE: This open-label pilot study aimed to evaluate and compare the efficacy and tolerability of risperidone and aripiprazole for treating ADHD symptoms in patients with both ASD and ADHD over the course of 24 weeks of treatment. METHODS:Patients (n = 44) were randomly assigned to start treatment with risperidone (22 patients) or aripiprazole (22 patients). Children were evaluated before starting treatment (T0), and after 12 weeks (T1) and 24 weeks (T2) of treatment. At each visit, specific psychiatric clinical scales were administered to assess the efficacy of the two drugs. RESULTS: The mean age was 8.4 ± 2.9 years in the aripiprazole group and 7.8 ± 2.3 years in the risperidone group. A total of 37 children (29 boys and 8 girls) completed the study (18 in the aripiprazole group and 19 in the risperidone group). Aripiprazole and risperidone appeared to have similar benefits in terms of efficacy and tolerability, although there were slight differences between the two drugs. Both groups showed a significant improvement in ADHD symptoms after 24 weeks of treatment (ADHD Rating Scale, Conners Parent Rating Scale-Hyperactivity, and Clinical Global Improvement-Severity Scale). No significant difference between the two drugs on any parameters at 24 weeks were found. Prolactin levels were decreased in the aripiprazole group. Both drugs were well tolerated, with no serious adverse events detected. CONCLUSIONS: Our study confirms the efficacy of both aripiprazole and risperidone in ameliorating ADHD symptoms of children also presenting with ASD.
Authors: Adelaide S Robb; Candace Andersson; Elizabeth E Bellocchio; George Manos; Carlos Rojas-Fernandez; Suja Mathew; Ronald Marcus; Randall Owen; Raymond Mankoski Journal: Prim Care Companion CNS Disord Date: 2011
Authors: Ronald N Marcus; Randall Owen; George Manos; Raymond Mankoski; Lisa Kamen; Robert D McQuade; William H Carson; Patricia K Corey-Lisle; Michael G Aman Journal: J Child Adolesc Psychopharmacol Date: 2011-06 Impact factor: 2.576
Authors: Ronald N Marcus; Randall Owen; Lisa Kamen; George Manos; Robert D McQuade; William H Carson; Michael G Aman Journal: J Am Acad Child Adolesc Psychiatry Date: 2009-11 Impact factor: 8.829
Authors: Meredith Matone; Russell Localio; Yuan-Shung Huang; Susan dosReis; Chris Feudtner; David Rubin Journal: Health Serv Res Date: 2012-09-04 Impact factor: 3.402
Authors: Hamza A Alsayouf; Haitham Talo; Marisa L Biddappa; Mohammad Qasaymeh; Shadi Qasem; Emily De Los Reyes Journal: Neuropsychiatr Dis Treat Date: 2020-11-16 Impact factor: 2.570
Authors: Gian Loreto D'Alò; Franco De Crescenzo; Laura Amato; Fabio Cruciani; Marina Davoli; Francesca Fulceri; Silvia Minozzi; Zuzana Mitrova; Gian Paolo Morgano; Franco Nardocci; Rosella Saulle; Holger Jens Schünemann; Maria Luisa Scattoni Journal: Health Qual Life Outcomes Date: 2021-01-25 Impact factor: 3.186
Authors: Giuseppe Cicala; Maria A Barbieri; Vincenza Santoro; Carmela Tata; Pia V Colucci; Francesca Vanadia; Flavia Drago; Carmelita Russo; Paola M Cutroneo; Antonella Gagliano; Edoardo Spina; Eva Germanò Journal: Front Psychiatry Date: 2020-03-24 Impact factor: 4.157