| Literature DB >> 27275921 |
Guosheng Song1, Yuyan Chen1, Chao Liang1, Xuan Yi2, Jingjing Liu1, Xiaoqi Sun1, Sida Shen1, Kai Yang2, Zhuang Liu1.
Abstract
A novel type of bio-nanoreactor with catalase loaded inside TaOx hollow nanoshells is fabricated via a mild one-step method. Such bio-nanoreactors could efficiently improve the tumor oxygenation by supplying oxygen via decomposition of endogenic H2 O2 in a tumor microenvironment, and thus synergistically enhance the efficacy of cancer radiotherapy by both depositing radiation energy within the tumor and overcoming hypoxia-induced radiotherapy resistance.Entities:
Keywords: bio-nanoreactors; enzyme delivery; hypoxia; radiotherapy; tantalum oxide
Mesh:
Substances:
Year: 2016 PMID: 27275921 DOI: 10.1002/adma.201602111
Source DB: PubMed Journal: Adv Mater ISSN: 0935-9648 Impact factor: 30.849