Mehmet Bulut1, Barış Özgür Dönmez2, Nihal Öztürk3, Göksun Başaranlar3, Ceren Kencebay Manas3, Narin Derin3, Semir Özdemir3. 1. Department of Ophthalmology, Antalya Education and Research Hospital, Antalya 07070, Turkey. 2. Department of Nutrition and Dietetics, School of Health, Akdeniz University, Antalya 07070, Turkey. 3. Department of Biophysics, Faculty of Medicine, Akdeniz University, Antalya 07070, Turkey.
Abstract
AIM: To evaluate the effect of sodium tungstate on visual evoked potentials (VEPs) in diabetic rats. METHODS: Wistar rats were randomly divided into three groups as normal control, diabetic control and diabetic rats treated with sodium tungstate. Diabetes was induced by single intraperitoneal injection of streptozotocin (50 mg/kg). Sodium tungstate [40 mg/(kg·d)] was administered for 12wk and then VEPs were recorded. Additionally, thiobarbituric acid reactive substance (TBARS) levels were measured in brain tissues. RESULTS: The latencies of P1, N1, P2, N2 and P3 waves were significantly prolonged in diabetic rats compared with control group. Diabetes mellitus caused an increase in the lipid peroxidation process that was accompanied by changes in VEPs. However, prolonged latencies of VEPs for all components returned to control levels in sodium tungstate-treated group. The treatment of sodium tungstate significantly decreased brain TBARS levels and depleted the prolonged latencies of VEP components compared with diabetic control group. CONCLUSION: Sodium tungstate shows protective effects on visual pathway in diabetic rats, and it can be worthy of further study for potential use.
AIM: To evaluate the effect of sodium tungstate on visual evoked potentials (VEPs) in diabeticrats. METHODS:Wistar rats were randomly divided into three groups as normal control, diabetic control and diabeticrats treated with sodium tungstate. Diabetes was induced by single intraperitoneal injection of streptozotocin (50 mg/kg). Sodium tungstate [40 mg/(kg·d)] was administered for 12wk and then VEPs were recorded. Additionally, thiobarbituric acid reactive substance (TBARS) levels were measured in brain tissues. RESULTS: The latencies of P1, N1, P2, N2 and P3 waves were significantly prolonged in diabeticrats compared with control group. Diabetes mellitus caused an increase in the lipid peroxidation process that was accompanied by changes in VEPs. However, prolonged latencies of VEPs for all components returned to control levels in sodium tungstate-treated group. The treatment of sodium tungstate significantly decreased brain TBARS levels and depleted the prolonged latencies of VEP components compared with diabetic control group. CONCLUSION:Sodium tungstate shows protective effects on visual pathway in diabeticrats, and it can be worthy of further study for potential use.
Authors: Sanne M Manschot; Willem Hendrik Gispen; L Jaap Kappelle; Geert Jan Biessels Journal: Diabetes Metab Res Rev Date: 2003 Nov-Dec Impact factor: 4.876