| Literature DB >> 27271512 |
Élica Renata Soares da Silva1,2, Gustavo Ruivo Salmazzo3, Jucicléia da Silva Arrigo4, Rodrigo Juliano Oliveira5, Candida Aparecida Leite Kassuya4, Cláudia Andréa Lima Cardoso6,7.
Abstract
Campomanesia xanthocarpa (Myrtaceae) is used in Brazilian traditional medicine against fever, diabetes, hypercholesteremic, obesity, and urinary diseases. In the present study, the compounds 2',6'-dihydroxy-3'-methyl-4'-metoxychalcone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone were identified for the first time in leaves of the C. xanthocarpa. These compounds and the hydroethanolic extract (HECX) significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. No toxicity was detected by HECX in an acute toxicity test.Entities:
Keywords: Campomanesia xanthocarpa; Myrtaceae; guavira; inflammation
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Year: 2016 PMID: 27271512 DOI: 10.1007/s10753-016-0378-3
Source DB: PubMed Journal: Inflammation ISSN: 0360-3997 Impact factor: 4.092