Tomohiko Nakamura1,2, Masashi Suzuki1, Akinori Okada1, Junichiro Suzuki1, Satoru Hasegawa3, Haruki Koike1, Masaaki Hirayama1,4, Masahisa Katsuno1, Gen Sobue5. 1. Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan. 2. Department of Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan. 3. Division of Neurogenetics, Nagoya University Graduate School of Medicine, Nagoya, Japan. 4. Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan. 5. Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan. sobueg@med.nagoya-u.ac.jp.
Abstract
INTRODUCTION: Leptin is involved in the regulation of blood pressure; however, no studies have evaluated the role of leptin in blood pressure changes during orthostatic stress in PD patients. The aim of this study was to determine whether plasma leptin levels influence orthostatic blood pressure changes in PD patients. METHODS: We enrolled 55 patients and 25 age-matched healthy controls in this study. Associations between head-up tilt test measurements and leptin levels were evaluated. RESULTS: Systolic blood pressure changes during the head-up tilt tests were strongly correlated with leptin levels at baseline and at a 60-degree head-up tilt in PD patients, but not in control subjects. Multiple regression analysis also demonstrated that leptin levels were associated with orthostatic blood pressure changes. CONCLUSION: These observations suggest that low leptin levels may be associated with orthostatic hypotension during the head-up tilt test in patients with PD.
INTRODUCTION:Leptin is involved in the regulation of blood pressure; however, no studies have evaluated the role of leptin in blood pressure changes during orthostatic stress in PDpatients. The aim of this study was to determine whether plasma leptin levels influence orthostatic blood pressure changes in PDpatients. METHODS: We enrolled 55 patients and 25 age-matched healthy controls in this study. Associations between head-up tilt test measurements and leptin levels were evaluated. RESULTS: Systolic blood pressure changes during the head-up tilt tests were strongly correlated with leptin levels at baseline and at a 60-degree head-up tilt in PDpatients, but not in control subjects. Multiple regression analysis also demonstrated that leptin levels were associated with orthostatic blood pressure changes. CONCLUSION: These observations suggest that low leptin levels may be associated with orthostatic hypotension during the head-up tilt test in patients with PD.