| Literature DB >> 27267460 |
Philip Rising Nielsen1, Tue Wenzel Kragstrup2, Bent Winding Deleuran2, Michael Eriksen Benros3.
Abstract
Viruses, bacteria and other infectious pathogens are the major postulated environmental triggers of autoimmunity. In the present nation-wide study we describe the association between infections and 29 autoimmune diseases. We used the Danish Civil Registration System to identify 4.5 million persons born between 1945 and 2000. Information on infections and autoimmune diseases was obtained from the Danish Hospital Register. The cohort was followed from 1977 to 2012. Incidence rate ratios for developing an autoimmune disease were estimated using poisson regression. We found an association between hospital admission for an infection and 29 autoimmune diseases. This study shows that infections are risk factors for a broad spectrum of autoimmune diseases in a dose-response and temporal manner, in agreement with the hypothesis that infections are an environmental risk factor contributing to the etiology of autoimmune diseases together with genetic factors.Entities:
Keywords: Autoimmune disease; Epidemiology; Infections
Mesh：
Year: 2016 PMID： 27267460 DOI： 10.1016/j.jaut.2016.05.013
Source DB: PubMed Journal: J Autoimmun ISSN： 0896-8411 Impact factor: 7.094