Jing Jiang1,2, Zhi-Fang Jia2, Dong-Hui Cao2, Yan-Hua Wu2, Zhi-Wei Sun1, Xue-Yuan Cao3. 1. Beijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing, PR China. 2. Division of Clinical Research, First Hospital of Jilin University, Changchun, PR China. 3. Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, PR China.
Abstract
AIM: Single nucleotide polymorphisms in miRNA-coding region may be involved in the development or progression of gastric cancer (GC). MATERIALS & METHODS: Six SNPs (miR-146a rs2910164, miR-196a2 rs11614913, miR-27a rs895819, miR-423 rs6505162, miR-608 rs4919510, miR-149 rs2292832) were genotyped in 898 histologically confirmed GC cases and 992 controls in this hospital-based case-control study. RESULTS: The G/G genotype of rs2910164 was associated with reduced risk of GC (odds ratio: 0.76, 95% CI: 0.60-0.97; p = 0.024). Meanwhile, in 838 GC cases receiving radical tumorectomy, cases bearing the G/G genotype of rs2910164 had shorter survival time comparing to cases with C/C or C/G genotype (hazard ratio: 1.36, 95% CI: 1.04-1.78, p = 0.023). CONCLUSION: rs2910164 of miR-146a is associated with GC.
AIM: Single nucleotide polymorphisms in miRNA-coding region may be involved in the development or progression of gastric cancer (GC). MATERIALS & METHODS: Six SNPs (miR-146ars2910164, miR-196a2rs11614913, miR-27ars895819, miR-423rs6505162, miR-608rs4919510, miR-149rs2292832) were genotyped in 898 histologically confirmed GC cases and 992 controls in this hospital-based case-control study. RESULTS: The G/G genotype of rs2910164 was associated with reduced risk of GC (odds ratio: 0.76, 95% CI: 0.60-0.97; p = 0.024). Meanwhile, in 838 GC cases receiving radical tumorectomy, cases bearing the G/G genotype of rs2910164 had shorter survival time comparing to cases with C/C or C/G genotype (hazard ratio: 1.36, 95% CI: 1.04-1.78, p = 0.023). CONCLUSION:rs2910164 of miR-146a is associated with GC.