Y Zhang1, Z Peng, L Chen. 1. Department of General Surgery, General Hospital of Chinese People's Liberation Army, Beijing 100853, China.
Abstract
OBJECTIVE: To study the survival situation of gastric cancer patients with pathological complete response (pCR)following neoadjuvant chemotherapy (NAC). METHODS: The clinical data of patients with gastric cancer treated with NAC following by surgical resection between Jan 2011 and Dec 2013 at General Hospital of Chinese People's Liberation Army was analyzed retrospectively. RESULTS: A total of 23 patients (16.0%, 23/144)achieved pathologic complete response. The median follow-up time of the survivors was 42.8 (range 16.0-58.7)months. All patients underwent R0 resection and D2 lymphadenectomy. The overall survival and recurrence-free survival rates at 3 years were 95.7% and 90.3%. CONCLUSIONS: The patients with advanced gastric cancer after neoadjuvant chemotherapy have good prognosis. Modified chemotherapy regimens may further improve the pathological complete response rate.
OBJECTIVE: To study the survival situation of gastric cancerpatients with pathological complete response (pCR)following neoadjuvant chemotherapy (NAC). METHODS: The clinical data of patients with gastric cancer treated with NAC following by surgical resection between Jan 2011 and Dec 2013 at General Hospital of Chinese People's Liberation Army was analyzed retrospectively. RESULTS: A total of 23 patients (16.0%, 23/144)achieved pathologic complete response. The median follow-up time of the survivors was 42.8 (range 16.0-58.7)months. All patients underwent R0 resection and D2 lymphadenectomy. The overall survival and recurrence-free survival rates at 3 years were 95.7% and 90.3%. CONCLUSIONS: The patients with advanced gastric cancer after neoadjuvant chemotherapy have good prognosis. Modified chemotherapy regimens may further improve the pathological complete response rate.