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Literature DB >> 27262779

YAP/TAZ as therapeutic targets in cancer.

Francesca Zanconato¹, Giusy Battilana¹, Michelangelo Cordenonsi¹, Stefano Piccolo².

Abstract

The biology and regulation of YAP and TAZ, two closely related transcriptional regulators, are receiving increasing attention owing to their fundamental roles in organ growth, tissue repair and cancer. In particular, the widespread activation of YAP/TAZ in carcinomas, and the crucial role of YAP/TAZ activation for many 'hallmarks' of cancer are indicating YAP/TAZ as prime targets for designing anti-cancer drugs. Here, we start from the known modalities to regulate YAP/TAZ to highlight possible routes of therapeutic intervention.

Entities: Chemical

Mesh：

Substances：

Year: 2016 PMID： 27262779 PMCID： PMC6175256 DOI： 10.1016/j.coph.2016.05.002

Source DB: PubMed Journal: Curr Opin Pharmacol ISSN： 1471-4892 Impact factor: 5.547

65 in total

1. Role of TAZ as mediator of Wnt signaling.

Authors: Luca Azzolin; Francesca Zanconato; Silvia Bresolin; Mattia Forcato; Giuseppe Basso; Silvio Bicciato; Michelangelo Cordenonsi; Stefano Piccolo
Journal: Cell Date: 2012-12-13 Impact factor: 41.582

2. YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers.

Authors: Giorgio G Galli; Matteo Carrara; Wei-Chien Yuan; Christian Valdes-Quezada; Basanta Gurung; Brian Pepe-Mooney; Tinghu Zhang; Geert Geeven; Nathanael S Gray; Wouter de Laat; Raffaele A Calogero; Fernando D Camargo
Journal: Mol Cell Date: 2015-10-01 Impact factor: 17.970

3. Transduction of mechanical and cytoskeletal cues by YAP and TAZ.

Authors: Georg Halder; Sirio Dupont; Stefano Piccolo
Journal: Nat Rev Mol Cell Biol Date: 2012-08-16 Impact factor: 94.444

4. Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein.

Authors: Michael DeRan; Jiayi Yang; Che-Hung Shen; Eric C Peters; Julien Fitamant; Puiyee Chan; Mindy Hsieh; Shunying Zhu; John M Asara; Bin Zheng; Nabeel Bardeesy; Jun Liu; Xu Wu
Journal: Cell Rep Date: 2014-10-16 Impact factor: 9.423

5. Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.

Authors: Ajaybabu V Pobbati; Xiao Han; Alvin W Hung; Seetoh Weiguang; Nur Huda; Guo-Ying Chen; CongBao Kang; Cheng San Brian Chia; Xuelian Luo; Wanjin Hong; Anders Poulsen
Journal: Structure Date: 2015-10-22 Impact factor: 5.006

6. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

Authors: Xiaodong Feng; Maria Sol Degese; Ramiro Iglesias-Bartolome; Jose P Vaque; Alfredo A Molinolo; Murilo Rodrigues; M Raza Zaidi; Bruce R Ksander; Glenn Merlino; Akrit Sodhi; Qianming Chen; J Silvio Gutkind
Journal: Cancer Cell Date: 2014-05-29 Impact factor: 31.743

7. TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells.

Authors: M Bartucci; R Dattilo; C Moriconi; A Pagliuca; M Mottolese; G Federici; A Di Benedetto; M Todaro; G Stassi; F Sperati; M I Amabile; E Pilozzi; M Patrizii; M Biffoni; M Maugeri-Saccà; S Piccolo; R De Maria
Journal: Oncogene Date: 2014-02-17 Impact factor: 9.867

8. Tead and AP1 Coordinate Transcription and Motility.

Authors: Xiangfan Liu; Huapeng Li; Mihir Rajurkar; Qi Li; Jennifer L Cotton; Jianhong Ou; Lihua J Zhu; Hira L Goel; Arthur M Mercurio; Joo-Seop Park; Roger J Davis; Junhao Mao
Journal: Cell Rep Date: 2016-01-28 Impact factor: 9.423

9. MDP, a database linking drug response data to genomic information, identifies dasatinib and statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells.

Authors: Cristian Taccioli; Giovanni Sorrentino; Alessandro Zannini; Jimmy Caroli; Domenico Beneventano; Laura Anderlucci; Marco Lolli; Silvio Bicciato; Giannino Del Sal
Journal: Oncotarget Date: 2015-11-17

10. YAP and TAZ regulate skin wound healing.

Authors: Min-Jung Lee; Mi Ran Byun; Makoto Furutani-Seiki; Jeong-Ho Hong; Han-Sung Jung
Journal: J Invest Dermatol Date: 2013-08-09 Impact factor: 8.551

77 in total

1. Pathways Governing Polyethylenimine Polyplex Transfection in Microporous Annealed Particle Scaffolds.

Authors: Norman F Truong; Sasha Cai Lesher-Pérez; Evan Kurt; Tatiana Segura
Journal: Bioconjug Chem Date: 2018-12-18 Impact factor: 4.774

Review 2. Drug development against the hippo pathway in mesothelioma.

Authors: Gavitt A Woodard; Yi-Lin Yang; Liang You; David M Jablons
Journal: Transl Lung Cancer Res Date: 2017-06

Review 3. The assembly and function of perinuclear actin cap in migrating cells.

Authors: Miloslava Maninova; Josef Caslavsky; Tomas Vomastek
Journal: Protoplasma Date: 2017-01-18 Impact factor: 3.356

4. YAP/TAZ initiate and maintain Schwann cell myelination.

Authors: Matthew Grove; Hyukmin Kim; Maryline Santerre; Alexander J Krupka; Seung Baek Han; Jinbin Zhai; Jennifer Y Cho; Raehee Park; Michele Harris; Seonhee Kim; Bassel E Sawaya; Shin H Kang; Mary F Barbe; Seo-Hee Cho; Michel A Lemay; Young-Jin Son
Journal: Elife Date: 2017-01-26 Impact factor: 8.140

5. Platelets reduce anoikis and promote metastasis by activating YAP1 signaling.

Authors: Monika Haemmerle; Morgan L Taylor; Tony Gutschner; Sunila Pradeep; Min Soon Cho; Jianting Sheng; Yasmin M Lyons; Archana S Nagaraja; Robert L Dood; Yunfei Wen; Lingegowda S Mangala; Jean M Hansen; Rajesha Rupaimoole; Kshipra M Gharpure; Cristian Rodriguez-Aguayo; Sun Young Yim; Ju-Seog Lee; Cristina Ivan; Wei Hu; Gabriel Lopez-Berestein; Stephen T Wong; Beth Y Karlan; Douglas A Levine; Jinsong Liu; Vahid Afshar-Kharghan; Anil K Sood
Journal: Nat Commun Date: 2017-08-21 Impact factor: 14.919