| Literature DB >> 28124973 |
Matthew Grove1,2, Hyukmin Kim1,2, Maryline Santerre3, Alexander J Krupka4, Seung Baek Han1,2, Jinbin Zhai1,2, Jennifer Y Cho1, Raehee Park1,2, Michele Harris2, Seonhee Kim1,2, Bassel E Sawaya3, Shin H Kang1,2, Mary F Barbe2, Seo-Hee Cho1,2, Michel A Lemay4, Young-Jin Son1,2.
Abstract
Nuclear exclusion of the transcriptional regulators and potent oncoproteins, YAP/TAZ, is considered necessary for adult tissue homeostasis. Here we show that nuclear YAP/TAZ are essential regulators of peripheral nerve development and myelin maintenance. To proliferate, developing Schwann cells (SCs) require YAP/TAZ to enter S-phase and, without them, fail to generate sufficient SCs for timely axon sorting. To differentiate, SCs require YAP/TAZ to upregulate Krox20 and, without them, completely fail to myelinate, resulting in severe peripheral neuropathy. Remarkably, in adulthood, nuclear YAP/TAZ are selectively expressed by myelinating SCs, and conditional ablation results in severe peripheral demyelination and mouse death. YAP/TAZ regulate both developmental and adult myelination by driving TEAD1 to activate Krox20. Therefore, YAP/TAZ are crucial for SCs to myelinate developing nerve and to maintain myelinated nerve in adulthood. Our study also provides a new insight into the role of nuclear YAP/TAZ in homeostatic maintenance of an adult tissue.Entities:
Keywords: Egr2; Schwann cells; TEAD; Taz; demyelination; mouse; neuroscience
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Year: 2017 PMID： 28124973 PMCID： PMC5287714 DOI： 10.7554/eLife.20982
Source DB: PubMed Journal: Elife ISSN： 2050-084X Impact factor: 8.140