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Literature DB >> 27261482

So You Can Teach Old Fibroblasts New Tricks.

Amaya Virós¹, Maria Romina Girotti², Richard Marais².

Abstract

New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses β-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. Thus, the aging microenvironment in elderly patient skin activates a signaling pathway that drives more aggressive melanoma cell behavior. Cancer Discov; 6(6); 581-3. ©2016 AACR. ©2016 American Association for Cancer Research.

Entities: Chemical

Mesh：

Substances：

Year: 2016 PMID： 27261482 PMCID： PMC5321576 DOI： 10.1158/2159-8290.CD-16-0503

Source DB: PubMed Journal: Cancer Discov ISSN： 2159-8274 Impact factor: 39.397

10 in total

1. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.

Authors: Berna C Özdemir; Tsvetelina Pentcheva-Hoang; Julienne L Carstens; Xiaofeng Zheng; Chia-Chin Wu; Tyler R Simpson; Hanane Laklai; Hikaru Sugimoto; Christoph Kahlert; Sergey V Novitskiy; Ana De Jesus-Acosta; Padmanee Sharma; Pedram Heidari; Umar Mahmood; Lynda Chin; Harold L Moses; Valerie M Weaver; Anirban Maitra; James P Allison; Valerie S LeBleu; Raghu Kalluri
Journal: Cancer Cell Date: 2014-05-22 Impact factor: 31.743

2. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.

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Journal: Cancer Cell Date: 2015-01-22 Impact factor: 31.743

3. The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma.

Authors: Sandra C Paek; Kent A Griffith; Timothy M Johnson; Vernon K Sondak; Sandra L Wong; Alfred E Chang; Vincent M Cimmino; Lori Lowe; Carol R Bradford; Riley S Rees; Michael S Sabel
Journal: Cancer Date: 2007-01-01 Impact factor: 6.860

Review 4. Epidemiology and treatment of melanoma in elderly patients.

Authors: Susan Tsai; Charles Balch; Julie Lange
Journal: Nat Rev Clin Oncol Date: 2010-02-09 Impact factor: 66.675

5. Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system.

Authors: C M Balch; S J Soong; J E Gershenwald; J F Thompson; D S Reintgen; N Cascinelli; M Urist; K M McMasters; M I Ross; J M Kirkwood; M B Atkins; J A Thompson; D G Coit; D Byrd; R Desmond; Y Zhang; P Y Liu; G H Lyman; A Morabito
Journal: J Clin Oncol Date: 2001-08-15 Impact factor: 44.544

6. Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma.

Authors: Tobias Bald; Thomas Quast; Jennifer Landsberg; Meri Rogava; Nicole Glodde; Dorys Lopez-Ramos; Judith Kohlmeyer; Stefanie Riesenberg; Debby van den Boorn-Konijnenberg; Cornelia Hömig-Hölzel; Raphael Reuten; Benjamin Schadow; Heike Weighardt; Daniela Wenzel; Iris Helfrich; Dirk Schadendorf; Wilhelm Bloch; Marco E Bianchi; Claire Lugassy; Raymond L Barnhill; Manuel Koch; Bernd K Fleischmann; Irmgard Förster; Wolfgang Kastenmüller; Waldemar Kolanus; Michael Hölzel; Evelyn Gaffal; Thomas Tüting
Journal: Nature Date: 2014-02-26 Impact factor: 49.962

7. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.

Authors: Jihye Yun; Edouard Mullarky; Changyuan Lu; Kaitlyn N Bosch; Adam Kavalier; Keith Rivera; Jatin Roper; Iok In Christine Chio; Eugenia G Giannopoulou; Carlo Rago; Ashlesha Muley; John M Asara; Jihye Paik; Olivier Elemento; Zhengming Chen; Darryl J Pappin; Lukas E Dow; Nickolas Papadopoulos; Steven S Gross; Lewis C Cantley
Journal: Science Date: 2015-11-05 Impact factor: 47.728

8. Oxidative stress inhibits distant metastasis by human melanoma cells.

Authors: Elena Piskounova; Michalis Agathocleous; Malea M Murphy; Zeping Hu; Sara E Huddlestun; Zhiyu Zhao; A Marilyn Leitch; Timothy M Johnson; Ralph J DeBerardinis; Sean J Morrison
Journal: Nature Date: 2015-10-14 Impact factor: 49.962

9. Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.

Authors: Cecilia Herraiz; Fernando Calvo; Pahini Pandya; Gaia Cantelli; Irene Rodriguez-Hernandez; Jose L Orgaz; NaRa Kang; Tinghine Chu; Erik Sahai; Victoria Sanz-Moreno
Journal: J Natl Cancer Inst Date: 2015-10-13 Impact factor: 13.506

10. sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.

Authors: Amanpreet Kaur; Marie R Webster; Katie Marchbank; Reeti Behera; Abibatou Ndoye; Curtis H Kugel; Vanessa M Dang; Jessica Appleton; Michael P O'Connell; Phil Cheng; Alexander A Valiga; Rachel Morissette; Nazli B McDonnell; Luigi Ferrucci; Andrew V Kossenkov; Katrina Meeth; Hsin-Yao Tang; Xiangfan Yin; William H Wood; Elin Lehrmann; Kevin G Becker; Keith T Flaherty; Dennie T Frederick; Jennifer A Wargo; Zachary A Cooper; Michael T Tetzlaff; Courtney Hudgens; Katherine M Aird; Rugang Zhang; Xiaowei Xu; Qin Liu; Edmund Bartlett; Giorgos Karakousis; Zeynep Eroglu; Roger S Lo; Matthew Chan; Alexander M Menzies; Georgina V Long; Douglas B Johnson; Jeffrey Sosman; Bastian Schilling; Dirk Schadendorf; David W Speicher; Marcus Bosenberg; Antoni Ribas; Ashani T Weeraratna
Journal: Nature Date: 2016-04-04 Impact factor: 49.962