Jin-Kyu Park1, Ji-Young Lee2, Pil-Sung Yang1, Tae-Hoon Kim1, Eunsoon Shin3, Junbeom Park1, Jae-Sun Uhm1, Boyoung Joung1, Moon-Hyoung Lee1, Hui-Nam Pak4. 1. Yonsei University Health System, Seoul, Republic of Korea. 2. Cardiovascular Genome Center, Yonsei University Health System, Seoul, Republic of Korea. 3. DNA Link Incorporation, Seoul, Republic of Korea. 4. Yonsei University Health System, Seoul, Republic of Korea; Cardiovascular Genome Center, Yonsei University Health System, Seoul, Republic of Korea. Electronic address: hnpak@yuhs.ac.
Abstract
BACKGROUND: Radiofrequency catheter ablation (RFCA) for long-standing persistent atrial fibrillation (L-PeAF) is challenging and has a relatively high recurrence rate. We explored clinical and genetic characteristics associated with being good responders (no early or clinical recurrence within 12 months in the absence of anti-arrhythmic drugs) to RFCA among patients with L-PeAF. METHODS: Of 1319 patients in the Yonsei AF Ablation Cohort, this study included 141 consecutive patients with L-PeAF (80.9% male, age 57.8±9.7 years) who were followed >12 months after RFCA. RESULTS: During 25 (19-35) months follow-up, the recurrence rate was 39%, and 38 patients (27%) were categorized as good responders, those had a shorter AF duration (p=0.010), and smaller left atrial (LA) size (p=0.033) than others. The rs2106216 (16q22/ZFHX3) genetic polymorphism was independently associated with being a good responder in multivariate analysis (adjusted OR=2.70, 95% CI 1.41-5.14, p=0.003), after adjusting for LA size and AF duration. The rs2106261 had predictive value for clinical recurrence of AF after RFCA among patients with an AF duration 12-65 months (log rank, p=0.025). CONCLUSIONS: Despite a relatively high recurrence rate after RFCA for L-PeAF, patients with a shorter AF duration and smaller LA size showed a more favorable outcome. The rs2106216 polymorphism (ZFHX3) was independently associated with being good responders to RFCA for L-PeAF, especially with AF duration 12-65 months.
BACKGROUND: Radiofrequency catheter ablation (RFCA) for long-standing persistent atrial fibrillation (L-PeAF) is challenging and has a relatively high recurrence rate. We explored clinical and genetic characteristics associated with being good responders (no early or clinical recurrence within 12 months in the absence of anti-arrhythmic drugs) to RFCA among patients with L-PeAF. METHODS: Of 1319 patients in the Yonsei AF Ablation Cohort, this study included 141 consecutive patients with L-PeAF (80.9% male, age 57.8±9.7 years) who were followed >12 months after RFCA. RESULTS: During 25 (19-35) months follow-up, the recurrence rate was 39%, and 38 patients (27%) were categorized as good responders, those had a shorter AF duration (p=0.010), and smaller left atrial (LA) size (p=0.033) than others. The rs2106216 (16q22/ZFHX3) genetic polymorphism was independently associated with being a good responder in multivariate analysis (adjusted OR=2.70, 95% CI 1.41-5.14, p=0.003), after adjusting for LA size and AF duration. The rs2106261 had predictive value for clinical recurrence of AF after RFCA among patients with an AF duration 12-65 months (log rank, p=0.025). CONCLUSIONS: Despite a relatively high recurrence rate after RFCA for L-PeAF, patients with a shorter AF duration and smaller LA size showed a more favorable outcome. The rs2106216 polymorphism (ZFHX3) was independently associated with being good responders to RFCA for L-PeAF, especially with AF duration 12-65 months.
Authors: Daniela Husser; Petra Büttner; Laura Ueberham; Borislav Dinov; Philipp Sommer; Arash Arya; Gerhard Hindricks; Andreas Bollmann Journal: J Transl Med Date: 2017-04-05 Impact factor: 5.531
Authors: Mina K Chung; Anant Madabhushi; Thomas Atta-Fosu; Michael LaBarbera; Soumya Ghose; Paul Schoenhagen; Walid Saliba; Patrick J Tchou; Bruce D Lindsay; Milind Y Desai; Deborah Kwon Journal: BMC Med Imaging Date: 2021-03-09 Impact factor: 1.930